A placental growth factor is silenced in mouse embryos by the zinc finger protein ZFP568

Science
Peng YangTodd S Macfarlan

Abstract

Insulin-like growth factor 2 (IGF2) is the major fetal growth hormone in mammals. We identify zinc finger protein 568 (ZFP568), a member of the rapidly evolving Kruppel-associated box-zinc finger protein (KRAB-ZFP) family linked primarily to silencing of endogenous retroelements, as a direct repressor of a placental-specific Igf2 transcript (designated Igf2-P0) in mice. Loss of Zfp568, which causes gastrulation failure, or mutation of the ZFP568-binding site at the Igf2-P0 promoter causes inappropriate Igf2-P0 activation. Deletion of Igf2 can completely rescue Zfp568 gastrulation phenotypes through late gestation. Our data highlight the exquisite selectivity with which members of the KRAB-ZFP family repress their targets and identify an additional layer of transcriptional control of a key growth factor regulating fetal and placental development.

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Citations

Jul 17, 2018·Metallomics : Integrated Biometal Science·Agnieszka Belczyk-CiesielskaWojciech Bal
Jan 23, 2019·Epigenomics·Yukiko KawabataTomohiro Kono
Apr 10, 2020·PLoS Genetics·Miroslava OndičováColum P Walsh
Sep 14, 2019·Annual Review of Genetics·Melania BrunoTodd S Macfarlan
Aug 23, 2020·Viruses·Franziska K Geis, Stephen P Goff
Mar 9, 2019·Development·Michelle K Y SeahDaniel M Messerschmidt
Mar 12, 2020·Cells·Marta Machnik, Urszula Oleksiewicz
Jun 12, 2020·Proceedings of the National Academy of Sciences of the United States of America·Mathieu BoulardTimothy H Bestor
Sep 5, 2019·Genes & Development·Rachel L CosbyCédric Feschotte
Feb 23, 2020·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Grace FarmiloeFrank M J Jacobs
Aug 11, 2019·Epigenetics & Chromatin·Hui ShiAnne C Ferguson-Smith
Nov 12, 2020·Critical Reviews in Biochemistry and Molecular Biology·Joshua L SchwartzGene W Yeo
Jun 3, 2021·Genes & Development·Courtney W Hanna, Gavin Kelsey
Aug 7, 2021·Nature Reviews. Genetics·Anna D Senft, Todd S Macfarlan
Aug 27, 2021·Cellular and Molecular Gastroenterology and Hepatology·Joonyong LeeGuoli Dai
May 19, 2021·Cold Spring Harbor Perspectives in Biology·Feiyue Lu, Timothée Lionnet

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