A plaidoyer for 'systems immunology'

Immunological Reviews
Christophe BenoistDiane Mathis

Abstract

A complete understanding of the immune system will ultimately require an integrated perspective on how genetic and epigenetic entities work together to produce the range of physiologic and pathologic behaviors characteristic of immune function. The immune network encompasses all of the connections and regulatory associations between individual cells and the sum of interactions between gene products within a cell. With 30,000+ protein-coding genes in a mammalian genome, further compounded by microRNAs and yet unrecognized layers of genetic controls, connecting the dots of this network is a monumental task. Over the past few years, high-throughput techniques have allowed a genome-scale view on cell states and cell- or system-level responses to perturbations. Here, we observe that after an early burst of enthusiasm, there has developed a distinct resistance to placing a high value on global genomic or proteomic analyses. Such reluctance has affected both the practice and the publication of immunological science, resulting in a substantial impediment to the advances in our understanding that such large-scale studies could potentially provide. We propose that distinct standards are needed for validation, evaluation, and visualizatio...Continue Reading

Citations

Apr 25, 2012·Immunologic Research·Vipin NarangAlexandre Gouaillard
Apr 12, 2013·Proceedings of the National Academy of Sciences of the United States of America·Paul J Choi, Timothy J Mitchison
Feb 27, 2008·The Journal of Experimental Medicine·Marie-Hélène FortierPierre Thibault
Jan 12, 2011·Annual Review of Immunology·Ronald N GermainIain D C Fraser
Jan 1, 2009·Immunotherapy·Francesco M Marincola
May 1, 2009·Immunotherapy·Ena WangFrancesco M Marincola
Oct 31, 2013·Current Opinion in Immunology·Charles C Kim, Lewis L Lanier
Feb 5, 2013·Seminars in Immunology·Arnon AraziNir Hacohen
May 18, 2012·Trends in Parasitology·Tuan M TranPeter D Crompton
Nov 25, 2011·The Journal of Allergy and Clinical Immunology·Anthony BoscoFernando D Martinez
Dec 17, 2015·Trends in Immunology·Julie G BurelDenise L Doolan
Dec 6, 2014·European Journal of Immunology·Fuyan WangHaiming Wei
Feb 19, 2008·Molecular Immunology·Pierre BoudinotAdrien Six
May 8, 2010·Wiley Interdisciplinary Reviews. Systems Biology and Medicine·Martin Meier-SchellersheimFrederick Klauschen
Oct 1, 2008·Proteomics. Clinical Applications·Niroshan RamachandranJoshua Labaer
Apr 30, 2009·Molecular Systems Biology·Kfir OvedYoram Reiter
Dec 23, 2011·Microbial Biotechnology·Adrien SixDavid Klatzmann
Sep 29, 2011·Molecular Systems Biology·Etienne CaronClaude Perreault
Aug 29, 2006·Biochemical Pharmacology·Wim Vanden BergheGuy Haegeman
Dec 20, 2011·Immunity·Pawel MuranskiNicholas P Restifo
Dec 27, 2011·Immunity·Paola Di MeglioFrank O Nestle
Jul 6, 2016·BMC Bioinformatics·Trevor Clancy, Eivind Hovig
Dec 9, 2015·The Journal of Immunology : Official Journal of the American Association of Immunologists·Djamel Nehar-BelaidDavid Klatzmann
Nov 30, 2018·Wellcome Open Research·Armin DeffurNicola M Mulder
Dec 5, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Chantal BaronClaude Perreault
May 6, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Anthony BoscoPatrick G Holt
Nov 15, 2016·The Journal of Clinical Investigation·Hillary PearsonClaude Perreault
Feb 3, 2021·The Journal of Immunology : Official Journal of the American Association of Immunologists·Victor H Salinas, Olaf Stüve

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