A plant-produced vaccine protects mice against lethal West Nile virus infection without enhancing Zika or dengue virus infectivity

Vaccine
Huafang LaiQiang Chen

Abstract

West Nile virus (WNV) has caused multiple global outbreaks with increased frequency of neuroinvasive disease in recent years. Despite many years of research, there are no licensed therapeutics or vaccines available for human use. One of the major impediments of vaccine development against WNV is the potential enhancement of infection by related flaviviruses in vaccinated subjects through the mechanism of antibody-dependent enhancement of infection (ADE). For instance, the recent finding of enhancement of Zika virus (ZIKV) infection by pre-exposure to WNV further complicates the development of WNV vaccines. Epidemics of WNV and the potential risk of ADE by current vaccine candidates demand the development of effective and safe vaccines. We have previously reported that the domain III (DIII) of the WNV envelope protein can be readily expressed in Nicotiana benthamiana leaves, purified to homogeneity, and promote antigen-specific antibody response in mice. Herein, we further investigated the in vivo potency of a plant-made DIII (plant-DIII) in providing protective immunity against WNV infection. Furthermore, we examined if vaccination with plant-DIII would enhance the risk of a subsequent infection by ZIKV and Dengue virus (DENV)....Continue Reading

Citations

May 23, 2019·Human Vaccines & Immunotherapeutics·Sebastian Ulbert
Oct 28, 2019·Scientific Reports·Kaewta RattanapisitWaranyoo Phoolcharoen
Feb 6, 2020·Frontiers in Bioengineering and Biotechnology·Andrew G DiamosHugh S Mason
Aug 7, 2021·Vaccines·Srividhya VenkataramanMounir Abouhaidar
Sep 28, 2021·Frontiers in Immunology·Brandi T Johnson-WeaverHerman F Staats

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