A plausible model correlates prebiotic peptide synthesis with the primordial genetic code

Chemical Communications : Chem Comm
Jianxi YingYufen Zhao

Abstract

Aminoacyladenylates (5'-aa-AMPs) are key intermediates in peptide synthesis. Here we report analogs of 5'-aa-AMPs, namely nucleotide amidates (aa-N-NMPs), obtained under Hadean conditions. Significantly, dipeptides were detected from the above reactions and their yields varied with different nucleosides through the formation of different aa-N-NMPs. This model provides both prebiotic peptides and the primordial version of the genetic code through reactions that occurred under potentially prebiotic conditions.

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Citations

Mar 6, 2019·Life·Ziwei LiuRobert Pascal

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Methods Mentioned

BETA
NMR

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