A plausible role for the presence of internal shine-dalgarno sites.

Bioinformatics and Biology Insights
Lalit Ponnala

Abstract

The presence of nucleotide hybridization between the 3' end of 16S rRNA and mRNA sequence upstream of the start codon is well known in bacteria. In this paper, we detect the presence of such hybridization sites inside the coding regions of E. coli genes, and analyze their proximity to clusters of slow-translating codons. We study this phenomenon in genes of high and low expression separately. Based on our findings, we propose an explanation for the presence of RNA hybridization within the translated regions of bacterial genes.

References

Apr 17, 1979·Molecular & General Genetics : MGG·J SedlácekA Vítek
Jul 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·A Hui, H A de Boer
Jan 1, 1987·Annual Review of Biophysics and Biophysical Chemistry·C G Kurland, M Ehrenberg
Apr 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·J Shine, L Dalgarno
Aug 20, 2004·Nucleic Acids Research·Luis Rogelio Cruz-VeraGabriel Guarneros
Apr 1, 2006·Molecular Microbiology·Haining JinLeif A Isaksson
Oct 20, 2006·Nature·Gulnara YusupovaMarat Yusupov
Aug 21, 2007·Biology of the Cell·J Ross Buchan, Ian Stansfield
Mar 11, 2008·Nature·Jin-Der WenIgnacio Tinoco
Apr 23, 2008·EURASIP Journal on Bioinformatics & Systems Biology·Lalit PonnalaMladen A Vouk
Jul 16, 2008·Biotechnology Journal·Monica Marin
Feb 10, 2009·Nature Structural & Molecular Biology·Gong ZhangZoya Ignatova
Apr 11, 2009·Science·Grzegorz KudlaJoshua B Plotkin

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Datasets Mentioned

BETA
000913.2

Methods Mentioned

BETA
optical tweezers

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