Nov 1, 1975

A plea for a comparative approach to evaluation of the physiological significance of regulatory mechanism observed in in vitro studies

Medical Hypotheses
M C Scrutton

Abstract

Regulatory mechanisms proposed on the vasis of in vitro studies using purified enzymes should be evaluated for their physiological significance in different species and under various conditions. The procedures presently employed for such evaluation are examined, and it is suggested that difficulties of application or interpretation arise, especially in studies on highly differentiated organisms. The use of comparative enzymology as an alternative approach to this problem is proposed, using in the main data obtained in studies on pyruvate carboxylase to illustrate the potential of this method. Some problems which arise in the use of comparative studies in this context are considered.

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References

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Citations

Mentioned in this Paper

Enzymes, antithrombotic
Enzymatic Biochemistry
Research Methodology
Cell Differentiation Process
Enzymes for Treatment of Wounds and Ulcers
Plea
Catalysis
PC gene
Pyruvate Carboxylase
Enzymes, hematological

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