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A Pleiotropy-Informed Bayesian False Discovery Rate adapted to a Shared Control Design Finds New Disease Associations From GWAS Summary Statistics

bioRxiv

Feb 4, 2015

James Liley, C Jane Wallace

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Abstract

Genome-wide association studies (GWAS) have been successful in identifying single nucleotide polymorphisms (SNPs) associated with many traits and diseases. However, at existing sample sizes, these variants explain only part of the estimated heritability. Leverage of GWAS results from re...read more

Mentioned in this Paper

Single Nucleotide Polymorphism
Genome
Genome-Wide Association Study
EAF2 gene
Etiology
Genomics
Autoimmune Diseases
8
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  • A Pleiotropy-Informed Bayesian False Discovery Rate adapted to a Shared Control Design Finds New Disease Associations From GWAS Summary Statistics

    bioRxiv

    Feb 4, 2015

    James Liley, C Jane Wallace

    PMID: 990014886

    DOI: 10.1101/014886

    Abstract

    Genome-wide association studies (GWAS) have been successful in identifying single nucleotide polymorphisms (SNPs) associated with many traits and diseases. However, at existing sample sizes, these variants explain only part of the estimated heritability. Leverage of GWAS results from re...read more

    Mentioned in this Paper

    Single Nucleotide Polymorphism
    Genome
    Genome-Wide Association Study
    EAF2 gene
    Etiology
    8

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