A plug-and-play ratiometric pH-sensing nanoprobe for high-throughput investigation of endosomal escape

Biomaterials
Zhou J DengPaula T Hammond

Abstract

An important aspect in the design of nanomaterials for delivery is an understanding of its uptake and ultimate release to the cytosol of target cells. Real-time chemical sensing using a nanoparticle-based platform affords exquisite insight into the trafficking of materials and their cargo into cells. This versatile and tunable technology provides a powerful tool to probe the mechanism of cellular entry and cytosolic delivery of a variety of materials, allowing for a simple and convenient means to screen materials towards efficient delivery of therapeutics such as nucleic acids.

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Citations

Oct 28, 2016·Macromolecular Bioscience·Nachnicha KongkatigumjornGeorgina K Such
Apr 27, 2017·Macromolecular Bioscience·Claudia Battistella, Harm-Anton Klok
Jun 3, 2017·Dalton Transactions : an International Journal of Inorganic Chemistry·Tifeng XiaGuodong Qian
Nov 21, 2019·Angewandte Chemie·Natalie BoehnkePaula T Hammond
Jun 3, 2021·Journal of Controlled Release : Official Journal of the Controlled Release Society·Emily XuAlexandra S Piotrowski-Daspit
Jul 3, 2021·Nanomaterials·Saquib Ahmed M A PeerzadeIgor Sokolov
Nov 20, 2018·Bioconjugate Chemistry·Samuel A SmithGeorgina K Such

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