A pneumonia outbreak associated with a new coronavirus of probable bat origin.

Nature
Peng ZhouZheng-Li Shi

Abstract

Since the outbreak of severe acute respiratory syndrome (SARS) 18 years ago, a large number of SARS-related coronaviruses (SARSr-CoVs) have been discovered in their natural reservoir host, bats1-4. Previous studies have shown that some bat SARSr-CoVs have the potential to infect humans5-7. Here we report the identification and characterization of a new coronavirus (2019-nCoV), which caused an epidemic of acute respiratory syndrome in humans in Wuhan, China. The epidemic, which started on 12 December 2019, had caused 2,794 laboratory-confirmed infections including 80 deaths by 26 January 2020. Full-length genome sequences were obtained from five patients at an early stage of the outbreak. The sequences are almost identical and share 79.6% sequence identity to SARS-CoV. Furthermore, we show that 2019-nCoV is 96% identical at the whole-genome level to a bat coronavirus. Pairwise protein sequence analysis of seven conserved non-structural proteins domains show that this virus belongs to the species of SARSr-CoV. In addition, 2019-nCoV virus isolated from the bronchoalveolar lavage fluid of a critically ill patient could be neutralized by sera from several patients. Notably, we confirmed that 2019-nCoV uses the same cell entry recep...Continue Reading

Associated Clinical Trials

Apr 27, 2021·Gisele Sampaio Silva, Gisele Sampaio Silva
May 5, 2020·Mahmoud Motaz Elzembely

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Citations

Feb 8, 2020·Military Medical Research·Ying-Hui JinUNKNOWN , for the Zhongnan Hospital of Wuhan University Novel Coronavirus Management and Research Team, Evidence-Based Medicine Chap
Feb 15, 2020·Journal of Medical Virology·Xuan JiangMin-Hua Luo
Mar 1, 2020·Infectious Diseases of Poverty·Tian-Mu ChenLing Yin
Feb 23, 2020·Clinical Oral Investigations·Robinson Sabino-SilvaWalter L Siqueira
Mar 27, 2020·Pathogens·Saif Ur RehmanQingyou Liu
Feb 29, 2020·The Veterinary Record·Shao-Lun ZhaiDan Wang
Mar 7, 2020·Nature Reviews. Cardiology·Ying-Ying ZhengXiang Xie
Mar 28, 2020·Journal of Gastroenterology and Hepatology·Sunny H WongJoseph Jy Sung
Feb 13, 2020·Science China. Life Sciences·Xiang LiJie Cui
Feb 13, 2020·Euro Surveillance : Bulletin Européen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin·Benjamin J Cowling, Gabriel M Leung
Apr 3, 2020·Cellular & Molecular Immunology·Penghui Yang, Xiliang Wang
Apr 3, 2020·Journal of Medical Virology·Qing YeTing Zhang
Apr 9, 2020·Frontiers in Microbiology·Ning WangLanying Du
Mar 11, 2020·Antimicrobial Agents and Chemotherapy·Miguel Angel Martinez
Apr 15, 2020·Nature Medicine·Kristian G AndersenRobert F Garry
Feb 14, 2020·Tropical Medicine & International Health : TM & IH·Thirumalaisamy P Velavan, Christian G Meyer
Apr 17, 2020·European Radiology·Wenjing YangMinjie Lu
Mar 24, 2020·Cellular & Molecular Immunology·Meijuan ZhengZhigang Tian
Mar 30, 2020·Xenotransplantation·Tanja Opriessnig, Yao-Wei Huang
May 1, 2020·Current Cardiology Reports·Paul ChengJune-Wha Rhee
Apr 1, 2020·Journal of Medical Virology·Jahan S KhaliliYi Zhu
Apr 9, 2020·The Medical Journal of Australia·Lei ZhaElmer V Villanueva
Apr 9, 2020·Nature Microbiology·Wen-Hua KongMan-Qing Liu
Apr 11, 2020·Basic Research in Cardiology·Paola RizzoRoberto Ferrari
Apr 22, 2020·Zeitschrift für Gesundheitswissenschaften = Journal of public health·Mehrdad MohammadiAnderia Lucia do Nascimento Pinto
Apr 17, 2020·Postgraduate Medical Journal·Neeraj Sinha, Galit Balayla
Apr 23, 2020·Journal of Cellular and Molecular Medicine·Hua LiJunbo Ge
Apr 25, 2020·Journal of Biomolecular Structure & Dynamics·Sukanth Kumar EnmozhiJerrine Joseph
Mar 4, 2020·Nature Microbiology·UNKNOWN Coronaviridae Study Group of the International Committee on Taxonomy of Viruses
May 13, 2020·The Veterinary Quarterly·Ruchi TiwariAlfonso J Rodriguez-Morales
Apr 1, 2020·Nature·Jian ShangFang Li

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Datasets Mentioned

BETA
AY278488.2

Methods Mentioned

BETA
PCR
bronchoalveolar
ELISA
enzyme-linked immunosorbent assays
electron microscopy
PCRs
confocal microscopy

Software Mentioned

Geneious
MEGAHIT
MGmapper
Clone Manager Professional Suite
MAFFT
Ed
DNAStar
Simplot
RAxML
Sci

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