A point-process model of human heartbeat intervals: new definitions of heart rate and heart rate variability

American Journal of Physiology. Heart and Circulatory Physiology
Riccardo BarbieriEmery N Brown

Abstract

Heart rate is a vital sign, whereas heart rate variability is an important quantitative measure of cardiovascular regulation by the autonomic nervous system. Although the design of algorithms to compute heart rate and assess heart rate variability is an active area of research, none of the approaches considers the natural point-process structure of human heartbeats, and none gives instantaneous estimates of heart rate variability. We model the stochastic structure of heartbeat intervals as a history-dependent inverse Gaussian process and derive from it an explicit probability density that gives new definitions of heart rate and heart rate variability: instantaneous R-R interval and heart rate standard deviations. We estimate the time-varying parameters of the inverse Gaussian model by local maximum likelihood and assess model goodness-of-fit by Kolmogorov-Smirnov tests based on the time-rescaling theorem. We illustrate our new definitions in an analysis of human heartbeat intervals from 10 healthy subjects undergoing a tilt-table experiment. Although several studies have identified deterministic, nonlinear dynamical features in human heartbeat intervals, our analysis shows that a highly accurate description of these series at r...Continue Reading

References

Sep 1, 1991·Journal of Applied Physiology·Y Yamamoto, R L Hughson
Oct 1, 1991·The American Journal of Physiology·J P SaulR J Cohen
Aug 1, 1988·Journal of the Autonomic Nervous System·M PaganiA Malliani
Nov 1, 1982·The American Journal of Physiology·C BorstA J Dunning
Nov 1, 1980·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·D J EwingB F Clarke
Apr 1, 1994·The American Journal of Physiology·S M Pincus, A L Goldberger
Feb 1, 1993·IEEE Transactions on Bio-medical Engineering·A M BianchiS Cerutti
Feb 1, 1993·Journal of Applied Physiology·V NovakR Nadeau
Apr 1, 1993·The American Journal of Physiology·J HayanoT Fujinami
Sep 1, 1995·Journal of Applied Physiology·J A TaylorD R Seals
Mar 19, 1996·Proceedings of the National Academy of Sciences of the United States of America·G SugiharaK D Allan
Mar 1, 1996·Clinical Physiology·H TanakaO Thulesius
Oct 23, 1997·Nature·C S Poon, C K Merrill
Feb 26, 1998·Journal of Applied Physiology·J R HalliwillS L Mulvagh
Dec 9, 1998·The American Journal of Physiology·Y KimuraA Yajima
Mar 6, 1999·Journal of Applied Physiology·V PichotJ C Barthélémy
Jun 12, 1999·Nature·P C IvanovH E Stanley
Sep 29, 2000·IEEE Transactions on Bio-medical Engineering·G B StanleyR A Siegel
Dec 21, 2000·American Journal of Physiology. Heart and Circulatory Physiology·R ZhangB D Levine
Feb 13, 2001·Journal of Neuroscience Methods·R BarbieriE N Brown
Oct 11, 2001·Proceedings of the National Academy of Sciences of the United States of America·E N BrownV Solo
Jan 23, 2002·Neural Computation·Emery N BrownLoren M Frank
Feb 14, 2002·Journal of Applied Physiology·Thomas HeldtRoger G Mark
Jul 23, 2002·Journal of Applied Physiology·Roy FreemanMarcelo Risk
Oct 12, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Riccardo BarbieriJ Philip Saul
Nov 29, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Eran ToledoSolange Akselrod
Jun 14, 2003·Neural Computation·Anne C Smith, Emery N Brown
Jun 26, 2003·American Journal of Physiology. Endocrinology and Metabolism·John F LockwoodYuguang Shi
Apr 9, 2004·Neural Computation·Uri T EdenEmery N Brown

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Citations

Feb 22, 2012·Medical & Biological Engineering & Computing·Sandun KodituwakkuRiccardo Barbieri
Mar 27, 2010·Neural Computation·Ke Yuan, Mahesan Niranjan
Apr 28, 2011·Neural Computation·Andrew Zammit MangionGuido Sanguinetti
Oct 12, 2011·Biomedical Engineering Online·Andrea BraviAndrew J E Seely
May 18, 2013·Biomedical Engineering Online·Jerritta SelvarajSazali Yaacob
Jun 23, 2011·PloS One·Fausto LucenaNoboru Ohnishi
Apr 13, 2011·Aviation, Space, and Environmental Medicine·Lauren T LaCountVitaly Napadow
Nov 12, 2013·Neural Computation·Luca CitiRiccardo Barbieri
Jan 7, 2015·IEEE Journal of Biomedical and Health Informatics·Gaetano ValenzaRiccardo Barbieri
Mar 13, 2014·IEEE Journal of Biomedical and Health Informatics·Tobias WartzekSteffen Leonhardt
Jun 7, 2013·IEEE Transactions on Bio-medical Engineering·Premananda IndicRiccardo Barbieri
Mar 25, 2014·IEEE Transactions on Bio-medical Engineering·Václav ChudáčekMuriel Doret
Mar 16, 2007·IEEE Transactions on Bio-medical Engineering·Ayla ErgünEmery N Brown
Jun 22, 2012·IEEE Transactions on Bio-medical Engineering·Ikaro SilvaRoger G Mark
Aug 10, 2012·IEEE Transactions on Bio-medical Engineering·Luca CitiRiccardo Barbieri
Apr 6, 2016·Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences·G ValenzaE P Scilingo
Apr 6, 2016·Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences·F NikolaouG D Mitsis
Apr 6, 2016·Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences·Andrea DuggentoNicola Toschi
May 23, 2014·Scientific Reports·Gaetano ValenzaRiccardo Barbieri
Dec 17, 2015·Clinical Physiology and Functional Imaging·Cesar AbadFábio Nakamura
Mar 11, 2009·IEEE Transactions on Bio-medical Engineering·Zhe ChenRiccardo Barbieri
Feb 25, 2017·NeuroImage·Roberta ScloccoVitaly Napadow
Mar 23, 2017·Developmental Psychobiology·Lisa Ecklund-FloresWilliam P Fifer
Feb 22, 2017·Scientific Reports·Gaetano ValenzaRiccardo Barbieri
Jun 28, 2014·Methods of Information in Medicine·G ValenzaR Barbieri
Aug 18, 2017·IEEE Transactions on Bio-medical Engineering·Gaetano ValenzaRiccardo Barbieri
Aug 12, 2016·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Andres E CarrilloGlen P Kenny
Feb 23, 2010·IEEE Transactions on Bio-medical Engineering·Zhe ChenRiccardo Barbieri
Feb 16, 2018·Journal of Applied Physiology·Gaetano ValenzaRiccardo Barbieri
Jul 12, 2018·IEEE Transactions on Bio-medical Engineering·Gaetano ValenzaRiccardo Barbieri
Nov 22, 2018·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Jonathan Birjiniuk, Thomas Heldt
Sep 21, 2017·Pain·Ronald G Garcia, Vitaly Napadow
Mar 16, 2012·Annals of Biomedical Engineering·Mika P TarvainenHarry Scheinin
Oct 30, 2014·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Gaetano ValenzaRiccardo Barbieri
Aug 15, 2014·Cerebral Cortex·Roberta ScloccoVitaly Napadow
Apr 6, 2016·Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences·Roberta ScloccoRiccardo Barbieri
Jan 28, 2017·Computational and Mathematical Methods in Medicine·Tatjana TasicDragana Bajic
Nov 30, 2019·Animals : an Open Access Journal From MDPI·Chiara ScopaPaolo Baragli
Mar 11, 2020·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Ronald G GarciaJill M Goldstein
Jun 18, 2020·Biomedical Engineering Online·Milad Alizadeh MeghraziMilad Lankarany
Oct 4, 2020·Proceedings of the National Academy of Sciences of the United States of America·Sandya SubramanianEmery N Brown

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