A Poiseuille-based coronary angiographic index for prediction of fractional flow reserve

International Journal of Cardiology
Ronen JaffeBasil S Lewis

Abstract

Coronary revascularization is commonly based on the angiographic finding of percent diameter stenosis (%DS) >50 while lesion length (LL), which contributes to flow-limitation according to Poiseuille's equation, is disregarded. Fractional flow reserve (FFR) is superior to assessment of %DS for identifying flow-limiting lesions, but the technology is invasive and relatively expensive. We developed a Poiseuille-based angiographic index, incorporating both minimal lumen diameter (MLD) and LL, for improved assessment of the hemodynamic significance of intermediate coronary lesions. The present study was designed to test the hypothesis that the Poiseuille-based angiographic index correlated better with FFR measurements than angiographic assessment of %DS. We performed quantitative coronary angiography (QCA) and FFR measurements in 46 intermediate coronary lesions in 41 symptomatic patients referred for diagnostic coronary angiography. From QCA we determined LL, MLD and %DS and calculated an angiographic index, the LL/MLD(4) ratio. Mean LL was 14.2 ± 7.8 (range: 4.3-38.8) mm, MLD 1.4 ± 0.4 (range: 0.6-2.3) mm, %DS 46 ± 12 (range: 25-74) and FFR 0.85 ± 0.09 (range: 0.55-1.00). Fractional flow reserve correlated inversely with %DS (R=-0...Continue Reading

References

Aug 10, 2005·American Heart Journal·David BroshAmir Lerman
Jan 16, 2009·The New England Journal of Medicine·Pim A L ToninoUNKNOWN FAME Study Investigators
Feb 21, 2009·The New England Journal of Medicine·Patrick W SerruysUNKNOWN SYNTAX Investigators
Feb 2, 2010·Journal of the American College of Cardiology·Morton J Kern, Habib Samady
Jan 15, 2011·JACC. Cardiovascular Interventions·Argyrios NtalianisBernard De Bruyne

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Citations

Aug 11, 2019·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Hiroki ShibutaniIchiro Shiojima

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