PMID: 2102264Jan 1, 1990Paper

A polarographic study of the photodegradation of nitrendipine

Journal of Pharmaceutical and Biomedical Analysis
J A SquellaL J Núñez-Vergara

Abstract

Nitrendipine produces a well-defined polarographic peak due to the four-electron reduction of the nitro group. This peak is used for tracking the photodecomposition of nitrendipine in both UV light and daylight conditions. The results show that nitrendipine remains unaltered in the short time scale of a normal analytical procedure and no special care with visible light exposure is necessary. However nitrendipine is strongly altered with UV irradiation showing a first-order degradation kinetics. A degradation rate constant of 0.0665 min-1 with a t1/2 of 10.423 min has been obtained. The UV degradation product was isolated and identified as the nitro pyridine analogue of nitrendipine.

Citations

Jul 1, 1993·Journal of Photochemistry and Photobiology. B, Biology·M P CortésC Sunkel
Mar 20, 2004·Journal of Pharmaceutical and Biomedical Analysis·C YáñezJ A Squella
Mar 29, 2001·Journal of Pharmaceutical and Biomedical Analysis·D N Tipre, P R Vavia
Mar 15, 2001·Journal of Pharmaceutical and Biomedical Analysis·V MarinkovicS Stankovic
Jun 1, 2002·Journal of Pharmaceutical and Biomedical Analysis·A Alvarez-LuejeL J Núñez-Vergara
Oct 9, 2002·Journal of Pharmaceutical and Biomedical Analysis·Nuran OzaltinIncilay Süslü
Sep 1, 1992·Journal of Pharmaceutical Sciences·A L ZanoccoJ A Squella

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