A polygenic model with common variants may predict lung adenocarcinoma risk in humans

International Journal of Cancer. Journal International Du Cancer
Antonella GalvanTommaso A Dragani

Abstract

Genome-wide screening for genetic loci associated with risk of lung adenocarcinoma (ADCA) was carried out in pooled DNA using the Illumina 300K single-nucleotide polymorphism (SNP) array, in a joint analysis of 2 Italian case-control series matched by age, gender and smoking habit. The rare allele carrier status of 8 SNPs was associated with a decreased lung ADCA risk [odds ratios (OR): 0.6-0.8]. In a polygenic model characterized by additive and interchangeable effects, individuals carrying 2 to 6 rare alleles at these 8 SNPs showed a significant trend toward a decreased risk of lung ADCA (up to OR of 0.3). These results suggest the relevance of a polygenic model in the modulation of individual risk of lung ADCA in the general population.

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Citations

May 28, 2010·Journal of the National Cancer Institute·John P A IoannidisEvangelos Evangelou
Aug 13, 2009·American Journal of Epidemiology·Marta GwinnMuin J Khoury
Apr 17, 2012·Oral Oncology·Renu BhatnagarDhananjaya Saranath
Oct 11, 2014·World Journal of Clinical Oncology·Xiao-Min Niu, Shun Lu
Apr 1, 2014·Clinical Chemistry and Laboratory Medicine : CCLM·Chih-Chi KuoYa-Wen Lin
Dec 10, 2009·Current Opinion in Oncology

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