A Polymer Coating Transfer Enrichment Method for Direct Mass Spectrometry Analysis of Lipids in Biofluid Samples

Angewandte Chemie
Wenpeng ZhangZheng Ouyang

Abstract

A porous polymer coating transfer enrichment method is developed for the direct mass spectrometry (MS) analysis of lipids. The enrichment is fast (ca. 1 min) and enables the profiling and quantitation of lipids in small-volume biofluid samples. Coupled with a photochemical Paternò-Büchi reaction, this method enables the fast determination of lipid structure at the C=C location level and point-of-care lipid biomarker analysis.

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Citations

Dec 2, 2020·Mass Spectrometry Reviews·Jianghui SunNa Na
May 19, 2021·Nature Communications·Zishuai LiZheng Ouyang
Jun 8, 2021·Chemical Science·Yuchen WangZheng Ouyang
May 11, 2019·Analytical Chemistry·Wenpeng ZhangZheng Ouyang
Dec 24, 2021·Analytical Methods : Advancing Methods and Applications·Fangfang LuZhiping Zhang

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