A polymerase chain reaction-based assay for diagnosing varicella-zoster virus retinitis in patients with acquired immunodeficiency syndrome

American Journal of Ophthalmology
G A ShortD Chandler

Abstract

To develop a rapid, sensitive, and specific laboratory assay based on the polymerase chain reaction for the diagnosis of varicella-zoster virus retinitis in patients with acquired immunodeficiency syndrome (AIDS). We developed and tested a polymerase chain reaction-based assay for the detection of varicella-zoster virus DNA in vitreous samples. We attempted to detect varicella-zoster virus DNA in 14 vitreous samples from patients with AIDS and a clinical diagnosis of progressive outer retinal necrosis syndrome. For controls, we also attempted to detect varicella-zoster virus DNA in vitreous samples from 75 immunocompetent patients with vitreoretinal disease and 88 patients with AIDS and vitreoretinal inflammatory disease not related to progressive outer retinal necrosis syndrome. Varicella-zoster virus DNA was detected in 11 of 14 vitreous samples from AIDS patients with progressive outer retinal necrosis syndrome. All three samples that scored negative for varicella-zoster virus DNA came from eyes that had been treated aggressively with antiviral drugs and had clinically inactive disease at the time of vitreous biopsy. Varicella-zoster virus DNA was detected in only two of 75 control vitreous samples from immunocompetent patie...Continue Reading

References

Apr 1, 1992·The Journal of Infectious Diseases·M E DevlinR Cohrs
Aug 15, 1991·American Journal of Ophthalmology·T P MargolisJ J O'Donnell
Feb 1, 1988·The West Virginia Medical Journal·J L Neely
Jan 1, 1986·The Journal of Infectious Diseases·R MuenchJ Z Sullivan-Bolyai
Apr 1, 1995·American Journal of Ophthalmology·M K PinnolisB Kemp
May 1, 1995·American Journal of Ophthalmology·A R RutzenN A Rao
Jan 1, 1994·International Ophthalmology·G N Holland
Sep 1, 1993·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·J GarwegH Schmitz

❮ Previous
Next ❯

Citations

Jun 28, 2013·Indian Journal of Ophthalmology·Parthopratim Dutta MajumderJyotirmay Biswas
Jun 8, 2014·Disease-a-month : DM·Karl N Becker, Norbert M Becker
Jan 15, 2014·Current Ophthalmology Reports·Parisa TaravatiRussell N Van Gelder
Oct 18, 2014·Ocular Immunology and Inflammation·Madhuravasal Krishnan JananiHajib Naraharirao Madhavan
Feb 7, 2007·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Philip D YinMary E Wright
Jan 27, 2009·Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie·Sonia N YeungPaul J Mackenzie
Apr 8, 2015·Transplant Infectious Disease : an Official Journal of the Transplantation Society·G C W ChanS C W Tang
Apr 29, 2014·Ocular Immunology and Inflammation·Neha MohanSoumyava Basu
May 27, 2005·BMC Ophthalmology·Anthony J AldaveRichard L Abbott
Oct 30, 2016·BMC Ophthalmology·Argyrios ChronopoulosGabriele Thumann
Feb 1, 1997·American Journal of Ophthalmology·B E SilversteinT P Margolis
May 3, 2000·International Ophthalmology Clinics·B D GaynorE T Cunningham
Jun 4, 2005·Clinical & Experimental Ophthalmology·Weng T Ng, Patrick Versace
Aug 5, 1998·Ocular Immunology and Inflammation·R N Van Gelder, H J Kaplan
Jul 13, 2001·Ocular Immunology and Inflammation·R N Van Gelder
Jul 11, 2003·Ocular Immunology and Inflammation·Russell N Van Gelder
Jul 9, 1999·Reviews in Medical Virology·D C Ritterband, D N Friedberg
Jun 4, 2015·International Ophthalmology Clinics·Jessica G ShanthaSteven Yeh
Jul 19, 2013·Postgraduate Medical Journal·Robert William WongEmmett T Cunningham
Nov 18, 1998·Journal of Clinical Microbiology·C M KnoxD Dean
Mar 25, 2004·Journal français d'ophtalmologie·T H C TranP LeHoang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.