A polymorphic variation in the interleukin 1A gene increases brain microglial cell activity in Alzheimer's disease

Journal of Neurology, Neurosurgery, and Psychiatry
A HayesD M A Mann

Abstract

To investigate the impact of possession of the -889 C/T polymorphism of the interleukin 1A gene (IL-1A) and the -511 C/T polymorphism of the interleukin 1B gene (IL-1B) on the extent of neuroinflammation in the brain in Alzheimer's disease (AD), as demonstrated by the degree of microglial cell activity associated with each IL-1A and IL-1B genotype. Microglial cell activity within the frontal cortex was determined in 68 patients with necropsy confirmed AD by image analysis as the percentage area of tissue occupied by ferritin immunostained material (microglial cell load). IL-1A, IL-1B, and apolipoprotein E (APOE) genotyping were performed by polymerase chain reaction on DNA extracted from frontal cortex or cerebellum. The microglial cell load was 31% greater in patients with IL-1A T allele, 62% greater with IL-1A TT genotype, but 108% greater with IL-1A TT genotype in combination with APOE epsilon4 allele. No effects on microglial cell load occurred with polymorphisms in IL-1B, or APOE alone. Polymorphisms within IL-1A influence the degree of brain microglial cell activation, especially in bearers of APOE epsilon4 allele, reinforcing the importance of neuroinflammatory processes in the pathogenesis of AD, and supporting the rati...Continue Reading

Citations

Aug 19, 2008·Cellular and Molecular Neurobiology·Ji-Liang HuYan-Jun Zeng
Feb 21, 2008·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·J InfanteO Combarros
Feb 10, 2007·Dementia and Geriatric Cognitive Disorders·Jon InfanteOnofre Combarros
Feb 4, 2010·Alzheimer's Research & Therapy·Elina ZotovaDelphine Boche
Jun 4, 2011·Genetics and Molecular Biology·Alex Augusto VendraminiSpencer Luiz Marques Payão
Jul 27, 2006·Acta Neurologica Scandinavica. Supplementum·A CagninR B Banati
May 14, 2005·Current Opinion in Neurology·Luisa Minghetti
Apr 14, 2017·Cellular and Molecular Neurobiology·Petr NovakPeter Filipcik
Feb 9, 2021·Journal of Alzheimer's Disease : JAD·Bijayani SahuColin K Combs
May 4, 2021·Journal of Alzheimer's Disease : JAD·Fahad Somaa

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