A polymorphism at the translation start site of the vitamin D receptor gene is associated with the response to anti-osteoporotic therapy in postmenopausal women from southern Italy

International Journal of Molecular Sciences
Valeria ContiAmelia Filippelli

Abstract

The present study investigated the effect of two single nucleotide polymorphisms (SNPs) of the vitamin D receptor (VDR) gene, rs1544410 A/G and rs2228570 C/T, in modulating bone mineral density (BMD) and the response to treatment with bisphosphonates or strontium ranelate in postmenopausal osteoporosis (PMO). Four hundred eighteen postmenopausal women from Southern Italy treated with bisphosphonates or strontium ranelate for three years were enrolled and stratified according to their genotype. Changes in BMD were expressed as the delta t-score (Δt-score). Allelic frequencies for rs1544410 A/GSNP were 11.2% AA, 50.0% GA and 38.8% GG; for rs2228570 C/TSNP were 54.8% CC, 39.5% TC and 5.7% TT. TT carriers showed a lower t-score than TC and CC (both p < 0.02) genotypes and were more responsive to the therapy when compared to both TC (p < 0.02) and CC (p < 0.05) carriers. Specifically, TT carriers receiving alendronate demonstrated a significant improvement of the Δt-score compared to TC and CC (both p < 0.0001) carriers. After adjustment for confounders, the Δt-score showed evidence of a statistically significant positive association with TT in all treatments considered. Therapy response was independent of rs1544410 A/G SNP; instead...Continue Reading

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Citations

Apr 14, 2016·International Journal of Molecular Sciences·Gloria Ravegnini, Sabrina Angelini
Dec 12, 2018·Journal of Orthopaedic Surgery and Research·Changyu PanJianmin Sun
May 11, 2017·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Elisabetta MamoliniGloria Bonaccorsi
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May 20, 2021·Journal of Orthopaedic Surgery and Research·Guo LiJiQiang Duan

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Methods Mentioned

BETA
X-ray
genotyping
hormone replacement therapy
ELISA
PCR

Software Mentioned

Statistical Package for the Social Sciences ( SPSS
PLINK
SPSS
Quanto

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