A polymorphism in the BCL-6 gene is associated with follicle center lymphoma

Leukemia & Lymphoma
Izidore S LossosR Levy

Abstract

Follicle center lymphoma (FCL) accounts for approximately 40% of all non-Hodgkin's lymphomas (NHL). The genetic-environmental interactions involved in the etiology and pathogenesis of this disease are unknown. In our previous study a single nucleotide polymorphism (SNP) (397C) in the regulatory untranslated first intron region of the BCL-6 gene was found in four of the eight FCL patients but in none of the 10 healthy controls. To further evaluate the potential association between the 397C allele of the BCL-6 gene and FCL, we performed a case-control study. Genomic DNA was isolated from 85 FCL patients, from 98 control cases without a previous history of malignancy, treated at Stanford University Medical Center for non-malignant disorders and from 90 samples from the DNA Polymorphism Discovery Resource. The 397G and the 397C polymorphic alleles were identified by a PCR-RFLP method. To evaluate the possible effect of this polymorphism on gene expression, BCL-6 mRNA levels in nine FCL tumors with the 397G-G genotype and in nine FCL tumors with the 397G-C genotype were measured by quantitative real-time RT-PCR. The 397C polymorphic allele was found in 32 FCL cases (37.6%), in 20 controls (20.4%) and in 17 (18.9%) samples from the D...Continue Reading

Citations

Apr 2, 2009·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Lindsay M MortonPatricia Hartge
Jul 4, 2007·Haematologica·Christine F SkibolaAlexandra Nieters
Jul 16, 2005·Hematology·Fabrice Jardin, Surinder S Sahota
Aug 12, 2006·Current Oncology Reports·Andrew J Davies
Apr 16, 2009·Leukemia & Lymphoma·Eloisa Jantus LewintreJavier García-Conde
May 26, 2016·Reproductive Sciences·Emily Evans-HoekerSteven L Young

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