A polypill for all? Critical review of the polypill literature for primary prevention of cardiovascular disease and stroke

The Annals of Pharmacotherapy
Katherine M CareyAbir O Kanaan

Abstract

To evaluate the efficacy and safety of the polypill for prevention of cardiovascular disease (CVD) and stroke and to present literature related to the polypill components (statin, aspirin, antihypertensive) for primary prevention of CVD and stroke. A literature search was conducted in MEDLINE (1948-January 2011) and EMBASE (1974-January 2011) using the terms polypill and Polycap. When limited to clinical trials, systematic reviews, or meta-analyses, 7 studies were identified. Bibliographies of pertinent review articles and studies were scanned for additional references. A similar search was conducted to identify literature related to the use of polypill components for primary prevention of CVD and stroke. Studies that evaluated the hypothetical benefits of a polypill and controlled trials that assessed a formulation of the polypill related to prevention of CVD and stroke were included. Studies were assessed for efficacy, safety, drug interactions, and clinical pharmacokinetics. An initial study to predict benefit estimated that a hypothetical polypill would reduce diastolic blood pressure by 11 mm Hg and low-density lipoprotein cholesterol (LDL-C) by 70 mg/dL, thus reducing the relative risks of CVD and stroke by 88% and 80%, r...Continue Reading

References

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Citations

Jan 28, 2014·Trends in Endocrinology and Metabolism : TEM·Hyeongsun MoonAndrew J Brown
Jan 20, 2016·Current Hypertension Reports·Steven G Chrysant, George S Chrysant
Sep 24, 2015·Journal of Controlled Release : Official Journal of the Controlled Release Society·Shaban A KhaledClive J Roberts
Jan 25, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Jian LiAiping Lu
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Nov 14, 2015·Journal of Korean Medical Science·Yun Sil ChangWon Soon Park
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Jun 25, 2016·Journal of Cardiovascular Medicine·Francesca Muscente, Raffaele De Caterina
May 8, 2018·Frontiers in Cardiovascular Medicine·Sai Wang SetoAlan Bensoussan
Jan 1, 2013·Journal of Drug Assessment·Niki KatsikiAsterios Karagiannis
Aug 28, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Xiao ZhuLiao Cui

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