A polysaccharide from natural Cordyceps sinensis regulates the intestinal immunity and gut microbiota in mice with cyclophosphamide-induced intestinal injury.

Food & Function
Shuping ChenShaoping Nie

Abstract

A polysaccharide from Cordyceps sinensis (NCSP) was reported to attenuate intestinal injury and regulate the balance of T helper (Th)1/Th2 cells in immunosuppressed mice. However, whether it influences Th17 and regulatory T (Treg) cells as well as gut ecology remains unknown. In the present study, the intestinal injury mouse model was also established by intraperitoneal injection of cyclophosphamide (Cy) for three consecutive days. NCSP was found to increase the number of CD4+ T cells, stimulate the secretion of interleukins (IL)-17 and IL-21, and the expression of transcription factor (retinoic acid-related orphan receptor (ROR)-γt). The levels of transforming growth factor (TGF)-β3 and transcription factor (forkhead box (Fox)p-3) were increased in NCSP-treated groups. Moreover, NCSP upregulated the mRNA expression of toll like receptors (TLR-2, -6 and -9), while it downregulated the TLR-4 expression. In addition, NCSP modulated the intestinal microbiota composition and increased the levels of SCFAs. These findings indicated that NCSP may enhance intestinal immunity and have the potential to become a prebiotic to regulate intestinal microbiota.

References

Jul 12, 2005·Veterinary Pathology·J A Ramos-Vara
Nov 8, 2006·Cell Research·Yeonseok ChungChen Dong
Jun 20, 2008·Nature·Estelle BettelliVijay K Kuchroo
Apr 4, 2009·Nature Reviews. Immunology·June L Round, Sarkis K Mazmanian
Jun 16, 2009·Current Opinion in Immunology·Yun Kyung LeeCasey T Weaver
Jan 16, 2010·Science·Akiko Iwasaki, Ruslan Medzhitov
May 22, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Hye-Ran ChaMi-Na Kweon
Dec 21, 2010·Nature Immunology·Kendle M Maslowski, Charles R Mackay
Apr 27, 2013·Nature Reviews. Immunology·Nobuhiko KamadaGabriel Núñez
Dec 20, 2015·Immunity·Dhavalkumar D Patel, Vijay K Kuchroo
Jul 10, 2016·Journal of Molecular Biology·Darrell W Cockburn, Nicole M Koropatkin
Sep 19, 2016·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Jensen H C YiuConnie W Woo
Oct 25, 2016·Frontiers in Immunology·Aranzazu Cruz-Adalia, Esteban Veiga
May 18, 2017·The Biochemical Journal·Elizabeth Thursby, Nathalie Juge
May 24, 2018·Nature Reviews. Gastroenterology & Hepatology·Hamed KhaliliAndrew T Chan
Jul 22, 2018·Food & Nutrition Research·Yueyue MengGuicheng Huo
Mar 11, 2020·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Mengxi YingMingyong Xie
Aug 15, 2020·Mucosal Immunology·Markus B Geuking, Regula Burkhard

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