A Pooled Analysis of Diffusion-Weighted Imaging Lesions in Patients With Acute Intracerebral Hemorrhage.

JAMA Neurology
Santosh B MurthyWendy C Ziai

Abstract

The etiology and significance of diffusion-weighted imaging (DWI) lesions in patients with acute intracerebral hemorrhage (ICH) remain unclear. To evaluate which factors are associated with DWI lesions, whether associated factors differ by ICH location, and whether DWI lesions are associated with functional outcomes. This analysis pooled individual patient data from 3 randomized clinical trials (Minimally Invasive Surgery Plus Alteplase for Intracerebral Hemorrhage Evacuation phase 3 trial, Antihypertensive Treatment of Acute Cerebral Hemorrhage trial, and Intracerebral Hemorrhage Deferoxamine phase 2 trial) and 1 multicenter prospective study (Ethnic/Racial Variations of Intracerebral Hemorrhage). Patients were enrolled from August 1, 2010, to September 30, 2018. Of the 4782 patients, 1788 who underwent magnetic resonance imaging scans of the brain were included. Data were analyzed from July 1 to December 31, 2019. The primary outcome consisted of factors associated with DWI lesions. Secondary outcomes were poor functional outcome, defined as a modified Rankin score (mRS) of 4 to 6, and mortality, both assessed at 3 months. Mixed-effects logistic regression was used to evaluate the association between exposures and outcomes. S...Continue Reading

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Citations

Jan 21, 2021·Stroke; a Journal of Cerebral Circulation·Santosh B MurthyWendy C Ziai
Jan 12, 2021·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·Yuji ShigaHirofumi Maruyama
Apr 9, 2021·Stroke; a Journal of Cerebral Circulation·Joseph P BroderickStephan Mayer
Apr 11, 2021·Journal of the Neurological Sciences·Rajeev K GargThomas P Bleck
Jun 10, 2021·Journal of Neurology, Neurosurgery, and Psychiatry·Kim WiegertjesJoanna M Wardlaw
Jul 23, 2021·Neurocritical Care·Ashkan ShoamaneshUNKNOWN ATACH-2 and NETT investigators
Jul 24, 2021·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Tracey H FanJoao Gomes

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