A pooled analysis of seven randomized crossover studies of the palatability of cefdinir oral suspension versus amoxicillin/clavulanate potassium, cefprozil, azithromycin, and amoxicillin in children aged 4 to 8 years

Clinical Therapeutics
Cynthia HolasDolores Kapral

Abstract

This analysis of the results of 7 trials compared the taste and smell acceptability scores of cefdinir oral suspension and 4 other pediatric antibiotic oral suspensions--amoxicillin/clavulanate potassium, cefprozil, azithromycin, or generic amoxicillin--using a visual smile-face scale. Data from 7 randomized, single-blind, cross-over trials were pooled and analyzed. In each study, children aged 4 to 8 years were asked to taste and smell 2 different antibiotic suspensions and assign preference using a visual smile-face scale. Ratings were converted to a numeric score ranging from 5 (really good) to 1 (really bad). A total of 1011 healthy subjects were randomly assigned to 1 of 2 treatment-order groups; 965 were evaluable for the taste and smell analyses. Baseline demographics of evaluable subjects were similar among test groups. Approximately even proportions of participants were female or male (50.1 % vs 49.9%), most (84.1%) were white, and slightly more participants were aged 7 or 8 years rather than younger (age 4 years, 16.0%; age 5 years, 17.4%; age 6 years, 18.7%; age 7 years, 23.2%; age 8 years, 24.8%). Of the 965 children who tasted both antibiotic suspensions and determined their preference, 798 (82.7%) rated the taste ...Continue Reading

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Citations

Feb 17, 2007·British Journal of Clinical Pharmacology·Chiara M MeierUNKNOWN CHIld Project
Nov 15, 2011·Expert Opinion on Pharmacotherapy·Maurizio DestroEmilio Galli
Apr 4, 2015·Journal of Oncology Pharmacy Practice : Official Publication of the International Society of Oncology Pharmacy Practitioners·Hussain MullaRoderick Skinner
Feb 3, 2007·Expert Review of Anti-infective Therapy·Helio S Sader, Ronald N Jones
Apr 7, 2017·Chemical Senses·Michael G Tordoff
Oct 23, 2008·The Journal of Pediatrics·Elin Haf Davies, Catherine Tuleu

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