A pooled genome-wide association study identifies pancreatic cancer susceptibility loci on chromosome 19p12 and 19p13.3 in the full-Jewish population.

Human Genetics
Samantha A StreicherHarvey A Risch

Abstract

Jews are estimated to be at increased risk of pancreatic cancer compared to non-Jews, but their observed 50-80% excess risk is not explained by known non-genetic or genetic risk factors. We conducted a GWAS in a case-control sample of American Jews, largely Ashkenazi, including 406 pancreatic cancer patients and 2332 controls, identified in the dbGaP, PanScan I/II, PanC4 and GERA data sets. We then examined resulting SNPs with P < 10-7 in an expanded sample set, of 539 full- or part-Jewish pancreatic cancer patients and 4117 full- or part-Jewish controls from the same data sets. Jewish ancestries were genetically determined using seeded FastPCA. Among the full Jews, a novel genome-wide significant association was detected on chromosome 19p12 (rs66562280, per-allele OR = 1.55, 95% CI = 1.33-1.81, P = 10-7.6). A suggestive relatively independent association was detected on chromosome 19p13.3 (rs2656937, OR = 1.53, 95% CI = 1.31-1.78, P = 10-7.0). Similar associations were seen for these SNPs among the full and part Jews combined. This is the first GWAS conducted for pancreatic cancer in the increased-risk Jewish population. The SNPs rs66562280 and rs2656937 are located in introns of ZNF100-like and ARRDC5, respectively, and are k...Continue Reading

References

Mar 1, 1973·Journal of the National Cancer Institute·E L WynderJ G Fortner
Mar 15, 1997·Developmental Biology·X GongN Rosenthal
Jan 11, 2000·Nucleic Acids Research·S T SherryK Sirotkin
Aug 6, 2005·Cancer Genetics and Cytogenetics·Norma J NowakAnirban Maitra
Dec 7, 2006·Journal of the National Cancer Institute·Harvey A RischSteven A Narod
Jun 3, 2010·Nature Reviews. Genetics·Jonathan Marchini, Bryan Howie
Jun 16, 2010·Nature Reviews. Genetics·Alkes L PriceNick Patterson
Feb 1, 2011·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Ronald C EldridgeEric J Jacobs
Nov 4, 2011·American Journal of Epidemiology·Zhihong GongPaige M Bracci
Mar 29, 2012·Molecular Cancer·Sumit SandhuHao Ding
Nov 7, 2012·Nature·UNKNOWN 1000 Genomes Project ConsortiumGil A McVean
Nov 26, 2013·Pathology Oncology Research : POR·Lukasz PaschkeLudwik K Malendowicz
Apr 1, 2014·Current Opinion in Cell Biology·Dong Soo KangJeffrey L Benovic
Apr 20, 2014·PLoS Genetics·Jared O'ConnellJonathan Marchini
Aug 5, 2014·Nature Genetics·Brian M WolpinLaufey T Amundadottir
Sep 17, 2014·Nature Reviews. Genetics·John S WitteNaomi R Wray
Oct 17, 2015·Cellular and Molecular Life Sciences : CMLS·Ludovic DhontAlexandra Belayew
Oct 27, 2015·The Journal of Pathology·Wafa Abu-AlaininEithne Costello
Nov 22, 2015·Nucleic Acids Research·Matthew L SpeirW James Kent
Feb 26, 2016·Nature·Peter BaileySean M Grimmond
Mar 1, 2016·American Journal of Human Genetics·Kevin J GalinskyAlkes L Price
May 20, 2016·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Erica J ChildsAlison P Klein
Jul 30, 2017·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Samantha A StreicherHarvey A Risch
Feb 10, 2018·Nature Communications·Alison P KleinLaufey T Amundadottir
Mar 15, 2019·British Journal of Cancer·Tsuyoshi HamadaBrian M Wolpin

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Citations

Aug 21, 2020·Seminars in Cancer Biology·Manuel GentiluomoDaniele Campa

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Methods Mentioned

BETA
genotyping
PCA

Software Mentioned

SNPTEST
gnomAD
SHAPEIT
IMPUTE
PLINK
FastPCA
haploreg
Affymetrix

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