A population-based analysis of contemporary patterns of care in younger men (<60 years old) with localized prostate cancer

International Urology and Nephrology
Andrew T WongDavid Schreiber

Abstract

To analyze patterns of care in younger patients (<60 years old) with localized prostate cancer and to identify factors associated with selection of therapy using a large, population-based database. The Surveillance, Epidemiology, and End Results database was queried to identify men <60 years old diagnosed with localized prostate cancer between 2010 and 2011. Patients were determined to have undergone no active treatment, local therapy, radiation therapy (RT), or radical prostatectomy (RP). Univariate and multivariate logistic regression analyses were performed to identify factors associated with the use of definitive therapy. A total of 12,732 men were included in this analysis. For the entire cohort, 12.5 % received no definitive treatment, 61.6 % RP, 22.0 % RT, and 3.3 % RP with adjuvant RT. Among men with low-, intermediate-, and high-risk prostate cancer, 17.2, 7.1, and 15.9 %, respectively, received no definitive therapy. RP was the most common choice of definitive therapy, utilized in 74.6 % of patients. Adjuvant RT after RP was utilized in 16.2 % of cases with positive margin and/or pT3/pT4 disease. African-American race, single marital status, and Medicaid/no insurance were associated with a decreased likelihood of rece...Continue Reading

References

Mar 30, 2005·Cancer·Thomas D DenbergJohn F Steiner
Sep 17, 2009·JAMA : the Journal of the American Medical Association·Grace L Lu-YaoSiu-Long Yao
Apr 6, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jeffrey J TosoianH Ballentine Carter
Apr 14, 2012·The Journal of Urology·Sean P ElliottBeth A Virnig
Jul 20, 2012·The New England Journal of Medicine·Timothy J WiltUNKNOWN Prostate Cancer Intervention versus Observation Trial (PIVOT) Study Group
Jul 13, 2013·International Journal of Radiation Oncology, Biology, Physics·Richard K ValicentiUNKNOWN American Society for Radiation Oncology/American Urological Association
Sep 26, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Ayal A AizerPaul L Nguyen
Mar 7, 2014·The New England Journal of Medicine·Anna Bill-AxelsonJan-Erik Johansson
May 14, 2014·Nature Reviews. Urology·Claudia A SalinasKathleen A Cooney
Jun 17, 2014·The Journal of Urology·Usama MahmoodKaren E Hoffman
Dec 17, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Laurence KlotzAndrew Loblaw
Feb 19, 2015·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Malcolm D MasonPadraig Warde

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