A population-based association study of glutamate decarboxylase 1 as a candidate gene for autism.

Journal of Neural Transmission
Henriette Nørmølle ButtenschønOle Mors

Abstract

Linkage studies, genome-wide scans and screening of possible candidate genes suggest that chromosome 2q31 may harbour one or more susceptibility genes for autism. The glutamate decarboxylase gene 1 (GAD1) located within chromosome 2q31 encodes the enzyme, GAD67, catalyzing the production of gamma-aminobutyric acid (GABA) from glutamate. Numerous independent findings have suggested the GABAergic system to be involved in autism. The present study investigates a Danish population-based, case-control sample of 444 subjects with childhood autism and 444 controls. Nine single nucleotide polymorphisms (SNPs) comprising the GAD1 gene and the microsatellite marker D2S2381 were examined for association with autism. We found no association between childhood autism and any single marker or 2-5 marker haplotypes. However, a rare nine-marker haplotype was associated with childhood autism. We cannot exclude neither GAD1 as a susceptibility gene nor the possibility of another susceptibility gene for autism to be located on chromosome 2q31.

References

Jan 1, 1995·Psychological Medicine·A BaileyM Rutter
Jul 1, 1994·Journal of Child Psychology and Psychiatry, and Allied Disciplines·P BoltonM Rutter
Apr 10, 1999·Human Molecular Genetics·A PhilippeL van Malldergerme
Jul 27, 1999·American Journal of Human Genetics·N RischR M Myers
Jan 8, 2000·Acta Paediatrica. Supplement·B Nørgaard-Pedersen, H Simonsen
May 16, 2001·American Journal of Human Genetics·J D BuxbaumK L Davis
Aug 2, 2001·American Journal of Human Genetics·UNKNOWN International Molecular Genetic Study of Autism Consortium (IMGSAC)
Jan 16, 2002·American Journal of Human Genetics·Daniel J SchaidGregory A Poland
Jan 30, 2002·Journal of Autism and Developmental Disorders·G J BlattM L Bauman
Feb 13, 2002·American Journal of Medical Genetics·Yujun ShaoMargaret A Pericak-Vance
Mar 5, 2002·American Journal of Human Genetics·Yujun ShaoMargaret A Pericak-Vance
Apr 18, 2002·Proceedings of the National Academy of Sciences of the United States of America·Frank B DeanRoger S Lasken
Mar 17, 2004·American Journal of Human Genetics·Walter T AmbrosiusCarl D Langefeld
Apr 2, 2004·The American Journal of Psychiatry·Nicolas RamozJoseph D Buxbaum
Nov 16, 2004·Neuroscience Letters·Raquel RabionetMargaret A Pericak-Vance
Apr 5, 2005·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·M D LundorfO Mors
Oct 4, 2005·Journal of Medical Genetics·U HanneliusJ Kere
Oct 6, 2005·European Journal of Human Genetics : EJHG·Francesca BlasiUNKNOWN International Molecular Genetic Study of Autism Consortium (IMGSAC)
Mar 4, 2006·International Review of Neurobiology·Gene J Blatt
May 2, 2006·The American Journal of Psychiatry·Raquel RabionetMargaret A Pericak-Vance
Jun 14, 2006·Neurogenetics·Ann L CollinsMargaret A Pericak-Vance
Mar 31, 2007·Genetic Testing·Karina Meden SørensenPaal Skytt Andersen
May 23, 2007·Clinical Chemistry·Mads V HollegaardDavid M Hougaard
Sep 4, 2009·Journal of Autism and Developmental Disorders·Marlene B LauritsenPoul Thorsen
Jan 1, 2009·Language Learning and Development : the Official Journal of the Society for Language Development·Daniel J WeissAaron D Mitchel

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Citations

Sep 4, 2009·Journal of Autism and Developmental Disorders·Marlene B LauritsenPoul Thorsen
Aug 21, 2009·World Journal of Pediatrics : WJP·Arianna BenvenutoPaolo Curatolo
Feb 9, 2011·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Shun-Chiao ChangSusan L Santangelo
Jun 25, 2015·CNS Drugs·Lawrence K Fung, Antonio Y Hardan
Dec 12, 2012·The International Journal of Neuropsychopharmacology·Anwesha BanerjeeMarco Atzori

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