A population-based case-control study of human papillomavirus-type-16 seropositivity and incident high-grade dysplasia of the uterine cervix

International Journal of Cancer. Journal International Du Cancer
A O OlsenP Magnus

Abstract

In order to study the association between seropositivity against human papillomavirus-type-16 capsids and CIN II-III in the general population in ages at which high-grade cervical dysplasia arises, 90 cases and 216 controls participating in a population-based case-control study of incident CIN II-III, were analyzed for the presence of HPV antibodies, HPV DNA and for the influence of behavioral factors. A significantly higher proportion of cases than controls were seropositive. Of HPV-16-DNA-positive cases and controls, 42 and 14% respectively were seropositive. A similar proportion of seropositivity was found among the 172 cytologically normal, HPV-DNA-negative controls. However, seropositivity was closely linked to the sexual history of the women. Logistic-regression analyses, adjusting for sexual behavior, smoking history and educational level, revealed that CIN II-III was associated with HPV-16 seropositivity and with HPV DNA. Controlling for the presence of HPV DNA indicated that antibodies were not independently associated with CIN. The low correlation between the presence of HPV antibodies and DNA, the finding that the association between seropositivity and CIN depended on the presence of HPV DNA, and the association of s...Continue Reading

References

Nov 11, 1992·International Journal of Cancer. Journal International Du Cancer·N MuñozN Ascunce
Jan 27, 1995·International Journal of Cancer. Journal International Du Cancer·J DillnerU Stendahl
May 1, 1995·Journal of Virological Methods·C Eklund, J Dillner
Apr 1, 1995·The Journal of Infectious Diseases·M EvanderG Wadell
May 4, 1995·International Journal of Cancer. Journal International Du Cancer·A O OlsenP Magnus
Mar 1, 1995·The Journal of General Virology·A WikströmJ Dillner
Feb 1, 1994·The Journal of Infectious Diseases·A HildesheimM E Sherman
Jun 16, 1993·Journal of the National Cancer Institute·M H SchiffmanS Wacholder

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Citations

May 13, 2003·International Journal of Cancer. Journal International Du Cancer·Seema ParikhPaolo Boffetta
Mar 14, 2000·Seminars in Cancer Biology·J Dillner
Sep 14, 2010·Cell Host & Microbe·Joseph J Carter, Denise A Galloway
Apr 21, 1998·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·A O OlsenP Magnus
May 20, 2015·Asian Pacific Journal of Cancer Prevention : APJCP·Zhi-Chang LiuSi-Dong Chen

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