PMID: 9429231Jan 16, 1998Paper

A population-based case-control study of the CYP2D6 and GSTT1 polymorphisms and malignant brain tumors

Pharmacogenetics
Karl T KelseyJohn K Wiencke

Abstract

Previous studies of associations of metabolic polymorphisms with the occurrence of malignant brain tumors have suggested that there is a significantly increased risk of development of adult gliomas in individuals who carry a poor metabolizer CYP2D6 variant allele and the GSTT1 null genotype. To investigate this further, a population-based case control study of adult glioma in the San Francisco Bay area was conducted. Patients (n = 188) diagnosed with brain tumors and controls (n = 166) were enrolled using random digit dialing and were frequency matched for age, ethnicity and gender. Genotyping for the polymorphisms was performed using standard PCR-based techniques. The analysis of the data was restricted to Caucasians because the prevalence of these traits is known to vary by ethnicity. No overall association of either the GSTT1 null genotype or CYP2D6 homozygous variant PM genotype was observed with the occurrence of brain tumors. However, when stratified by histopathologic subtype, there was a significantly increased risk for oligodendroglioma associated with the GSTT1 null genotype, with an OR of 3.2 (95% CI 1.1-9.2). These data suggest that the GSTT1 polymorphism may play a role in the development of a subset of malignant b...Continue Reading

Citations

Feb 3, 2005·Acta Neuropathologica·Hiroko Ohgaki, Paul Kleihues
Mar 12, 2009·Journal of Exposure Science & Environmental Epidemiology·Ziad NaufalKirby C Donnelly
Jun 6, 2003·The Cancer Journal·Kenneth D AldapeMargaret Wrensch
Jun 11, 2005·Neuroepidemiology·Katie L MillerMargaret Wrensch
Jan 10, 2006·Neurosurgical Focus·Margaret WrenschKenneth D Aldape
Oct 30, 2007·Neurologic Clinics·James L FisherJoseph L Wiemels
Dec 15, 2005·International Journal of Cancer. Journal International Du Cancer·Pritha GhoshAshok K Giri
Jan 12, 2005·Cancer Genetics and Cytogenetics·Hatice PinarbasiMustafa Gurelik
Sep 15, 2009·Jornal brasileiro de pneumologia : publicaça̋o oficial da Sociedade Brasileira de Pneumologia e Tisilogia·Helen Naemi HonmaLair Zambon
Feb 24, 2007·European Journal of Pediatrics·Necati MusluUgur Atik
Apr 15, 2020·Academic Pathology·Sarah Zhang, Christopher William
Oct 20, 2012·Molecular Biology Reports·Zuoxu FanRenya Zhan

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