Abstract
We aimed to investigate the association between possible aetiological factors and the risk of developing vulval lichen sclerosus (VLS). A population-based case-control questionnaire study was performed comparing women with a diagnosis of VLS (n= 92), with those attending a general gynaecology clinic with no known anogenital dermatosis (n= 66). After adjustment for confounders, factors associated with VLS included a family history of diabetes mellitus (OR= 7.0, p= 0.012) and previous pelvic surgery (OR= 4.75, p= 0.007). The use of barrier and progesterone only methods of contraception (OR= 0.19, p= 0.045), hormone replacement therapy (OR= 0.209, p= 0.025) or hayfever (OR= 0.18, p= 0.008) appeared to be associated with a reduced risk of VLS. In conclusion, we were unable to confirm many proposed aetiological theories associated with the development of VLS, in particular those associated with autoimmunity.
References
Jul 1, 1989·American Journal of Obstetrics and Gynecology·M SideriG Cecchetti
Jan 1, 1988·The British Journal of Dermatology·R H Meyrick ThomasM M Black
Mar 1, 1986·The British Journal of Dermatology·R H Meyrick Thomas, C T Kennedy
Aug 1, 1985·Archives of Dermatology·V M YatesV K Dave
Sep 15, 1984·American Journal of Obstetrics and Gynecology·E G Friedrich, N K MacLaren
Oct 1, 1995·Journal of the American Academy of Dermatology·W I DillonD P Fivenson
May 1, 1994·Clinical and Experimental Dermatology·P ToddA Pembroke
May 1, 1993·The Journal of Investigative Dermatology·C SchemppH Gollnick
Dec 1, 1995·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·P CarliB Giannotti
May 29, 1999·Lancet·J J Powell, F Wojnarowska
Jun 3, 1999·The British Journal of Dermatology·A M FarrellF Wojnarowska
Dec 22, 1999·Clinical and Experimental Dermatology·A M FarrellF Wojnarowska
Mar 29, 2000·The British Journal of Dermatology·J PowellK Welsh
Mar 10, 2001·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·J. Scurry
Jun 7, 2002·Archives of Gynecology and Obstetrics·M HagedornT Bauknecht
Oct 9, 2002·The British Journal of Dermatology·S M NeillUNKNOWN British Association of Dermatologists
Jul 18, 2003·Lancet·Noritaka OyamaJohn A McGrath
Jan 1, 1997·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·V WalkdenF Wojnarowska
Oct 13, 2006·The British Journal of Dermatology·A M FarrellF Wojnarowska
Jan 16, 2007·The Australasian Journal of Dermatology·Susan Simpkin, Amanda Oakley
Dec 7, 2007·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Andreas R GünthertGünter Emons
May 2, 2008·Obstetrics and Gynecology
Nov 19, 2008·Archives of Dermatology·Susan M CooperFenella Wojnarowska
Aug 13, 2010·Journal of Psychosomatic Obstetrics and Gynaecology·Hedwig P Van de NieuwenhofJoanne A De Hullu
Sep 22, 2010·The British Journal of Dermatology·S M NeillUNKNOWN British Association of Dermatologists
Citations
Sep 8, 2012·Journal of General Internal Medicine·Jennifer E Potter, Kendra A Moore
Oct 27, 2015·Gynecologic Oncology·Veronica BoeroGiorgio Bolis
Jul 24, 2015·Journal of the European Academy of Dermatology and Venereology : JEADV·G KirtschigF Wojnarowska
Aug 16, 2016·Journal of the European Academy of Dermatology and Venereology : JEADV·A VirgiliUNKNOWN GLS Italian Study Group
Jul 25, 2017·International Journal of Dermatology·Anna K Hald, Jan Blaakaer
Jun 20, 2018·The Australian & New Zealand Journal of Obstetrics & Gynaecology·Yvonne NguyenGayle Fischer
Feb 13, 2013·Multiple Sclerosis : Clinical and Laboratory Research·Jun-ichi Satoh, Hiroko Tabunoki
Apr 8, 2020·Genetic Testing and Molecular Biomarkers·Guang-Qing DuanWei Tan
Mar 29, 2014·PloS One·Linda T HirakiAndrew T Chan
May 24, 2017·Immunopharmacology and Immunotoxicology·Zineb DjerabaChafia Touil-Boukoffa
May 3, 2014·PloS One·Pauli TuoresmäkiCarsten Carlberg
Sep 8, 2020·American Journal of Clinical Dermatology·Natalie M WilliamsAntonella Tosti
May 28, 2016·Deutsches Ärzteblatt International·Gudula Kirtschig
Aug 28, 2021·Biomedicines·Monica CorazzaAlessandro Borghi
Apr 30, 2021·Italian Journal of Dermatology and Venereology·Manuela PapiniUNKNOWN Mucous Membrane Disorders Research Group of SIDeMaST
Oct 20, 2021·Acta Dermato-venereologica·Niina HietaSakari Hietanen