Abstract
To determine neurocognitive, educational, and psychological functioning during childhood and early adolescence among survivors of early life meningitis who are apparently healthy. In the general population-based Avon Longitudinal Study of Parents and Children birth cohort, meningitis exposure was determined at age of 18 months. The outcomes of intelligence quotient, short-term memory, working memory, reading and spelling abilities, psychological and behavioral problems, depressive and anxiety symptoms, and psychotic experiences at ages 9 to 13 years were compared between those exposed and unexposed to meningitis. Individuals with special educational needs were excluded. By age of 18 months, 67 of 11,035 children were reported to have suffered from meningitis (0.61%). These children, compared with the unexposed, performed worse on all neurocognitive and educational measures; mean difference in total intelligence quotient 7.36 (95% confidence interval, 1.60-13.11). Meningitis was associated with higher depressive and anxiety symptoms (P = .02), psychological and behavioral problems (P = .09), and increased risk of psychotic experiences; risk ratio 2.22 (95% confidence interval, 1.12-4.38). Exposure to meningitis in the early life...Continue Reading
References
May 1, 1990·Archives of General Psychiatry·R HarringtonJ Hill
May 1, 1988·Archives of Disease in Childhood·G MahdiG Evans-Jones
Apr 1, 1994·Psychological Reports·E M Levinson, L Folino
Jul 1, 1993·Archives of Disease in Childhood·L HristevaA R Wilkinson
Jul 1, 1997·Journal of Child Psychology and Psychiatry, and Allied Disciplines·R Goodman
Jan 19, 2000·Journal of the American Academy of Child and Adolescent Psychiatry·D ShafferM E Schwab-Stone
Jul 8, 2000·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·S Sheth
Jul 25, 2000·Archives of Disease in Childhood·K GrimwoodT Nolan
Nov 14, 2000·Archives of General Psychiatry·R PoultonH Harrington
Aug 3, 2001·Seminars in Neonatology : SN·R A Polin, M C Harris
Nov 9, 2001·Journal of the American Academy of Child and Adolescent Psychiatry·R Goodman
Dec 11, 2003·Annals of Epidemiology·Fouad G YoussefFrank Mahoney
Sep 2, 2005·European Journal of Pediatrics·John de LouvoisDavid Harvey
May 2, 2006·Journal of Abnormal Child Psychology·Carla SharpTim J Croudace
Sep 2, 2008·The British Journal of Psychiatry : the Journal of Mental Science·Jeremy HorwoodGlynn Harrison
Mar 4, 2009·Pediatrics·Jennie BorgRussell M Viner
May 30, 2009·Vaccine·Lee H HarrisonMary E Ramsay
Sep 15, 2009·Lancet·Katherine L O'BrienUNKNOWN Hib and Pneumococcal Global Burden of Disease Study Team
Jan 9, 2010·Vaccine·Shamez LadhaniRobert Booy
Apr 27, 2010·The Lancet Infectious Diseases·Karen EdmondIgor Rudan
Jun 18, 2010·The Pediatric Infectious Disease Journal·Fatma LeventMorven S Edwards
Jan 20, 2011·European Journal of Pediatrics·Deborah ChristieRobert Booy
Mar 15, 2011·Vaccine·Susan S HuangJonathan A Finkelstein
Apr 18, 2012·International Journal of Epidemiology·Abigail FraserDebbie A Lawlor
Apr 18, 2012·International Journal of Epidemiology·Andy BoydGeorge Davey Smith
Jun 19, 2012·Schizophrenia Research·Golam M KhandakerPeter B Jones
Aug 7, 2012·Lancet Neurology·Russell M VinerDeborah Christie
May 4, 2013·The American Journal of Psychiatry·Stanley ZammitGlyn Lewis
Aug 2, 2013·The New England Journal of Medicine·Christopher J L Murray, Alan D Lopez
Oct 12, 2013·BMC Public Health·Laura J ClarkCaroline L Trotter
Citations
Oct 2, 2015·Aging and Disease·Tatiana BarichelloFelipe Dal-Pizzol
Jun 4, 2015·Psychopharmacology·Golam M Khandaker, Robert Dantzer
Jul 18, 2016·Comprehensive Psychiatry·Caroline SiebaldPeter B Jones
Sep 14, 2016·Brain, Behavior, and Immunity·Stephen A MetcalfGolam M Khandaker
Apr 7, 2018·Psychological Medicine·Nils KappelmannHåkan Karlsson
Jan 1, 2019·PloS One·Dawid GondekAlissa Goodman
Dec 5, 2017·Epidemiology and Infection·N MackinnonG M Khandaker
Aug 21, 2020·BMJ Open·Elisabetta ScanferlaPhilip Gorwood
Oct 27, 2017·Italian Journal of Pediatrics·Elena BozzolaAlberto Villani
May 26, 2017·PloS One·Iain T R KennedyShamez N Ladhani