PMID: 9432042Jan 31, 1998Paper

A population-based registry on paraproteinaemia in The Netherlands. Comprehensive Cancer Centre West, Leiden, The Netherlands

British Journal of Haematology
F OngJ C Kluin-Nelemans

Abstract

Patients with monoclonal gammopathies comprise a heterogenous group. The few studies on incidence and follow-up are single-centre-based and may reflect referral bias. To avoid this, all patients (n=1275) in midwestern Netherlands with a newly discovered paraproteinaemia in 1991, 1992 and 1993 were included in a population-based registry and divided into four major diagnostic groups: multiple myeloma and plasmacytoma (n=230, 18%), other haematological diseases (n=141, 11%), paraprotein-related internal diseases (n=191, 15%) and monoclonal gammopathy of undetermined significance (MGUS, n=713, 56%). To avoid a possibly erroneous diagnosis, patients who were classified as having MGUS but who did not undergo confirmatory bone marrow examination were included in a separate group 'provisional MGUS' (n=524, 41%), whereas patients who did were classified as having 'definite MGUS' (n=189, 15%). The 'provisional MGUS' patients were relatively older and had more often a poor performance status, but differences between this and the 'definite MGUS' group were otherwise small. Patients complaining of general malaise more often had a full work-up of their paraproteinaemia. Bone pain, hypercalcaemia, high total protein, and high ESR occurred pr...Continue Reading

Citations

Jun 3, 1998·British Journal of Haematology·P M CarliM Maynadié
Oct 16, 1999·British Journal of Haematology·C G SchaarJ C Kluin-Nelemans
Jul 9, 2002·British Journal of Haematology·Helga M OgmundsdóttirHrafn Tulinius
Nov 20, 2002·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Suvi BühlerKlaus Hedman
Jul 14, 2007·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Brenda M BirmannGraham A Colditz
Nov 28, 2008·British Journal of Haematology·Cees G SchaarHanneke Kluin-Nelemans
Sep 21, 2010·Cytometry. Part B, Clinical Cytometry·Mary L McMaster, Ola Landgren
May 19, 2007·La Presse médicale·Olivier DecauxBernard Grosbois
Nov 9, 2007·International Journal of Cancer. Journal International Du Cancer·Mary L McMaster, Gyorgy Csako
Aug 26, 1998·European Journal of Haematology·H GregersenJ F Dahlerup
Sep 6, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Mary L McMasterMargaret A Tucker
Aug 18, 2010·Mayo Clinic Proceedings·Rishi K Wadhera, S Vincent Rajkumar

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