A population-based study of Graves' disease in Danish twins

Clinical Endocrinology
Thomas Heiberg BrixLaszlo Hegedüs

Abstract

The aetiology of Graves' disease (GD) is generally thought to fit a multi-factorial pattern of inheritance in which clinical disease develops on the basis of genetic susceptibility interacting with environmental and endogenous factors. In previous twin studies the probandwise concordance rates for hyperthyroidism were as high as 0.86 in monozygotic twins and 0.20 in dizygotic twins, indicating a very strong genetic influence. In these studies, however, no effort was made to distinguish between GD and non-autoimmune hyperthyroidism, and one study also included patients with simple non-toxic goitre, hampering if not invalidating any conclusions. The aim of the present study was to determine whether there is a genetic contribution in the aetiology of GD. Historical cohort study of pairs of same-sex twins, with information on GD being gathered by questionnaire surveys in the 1950s and 1960s. All available hospital material was sought to verify the diagnosis, which was assigned on the basis of clinical and histopathological evidence. The healthy co-twins were followed through middle age by questionnaire surveys in the 1970s and 1980s. Same-sex twin individuals born between 1870-1920, included in a population-based nationwide registe...Continue Reading

References

May 18, 1979·Cell and Tissue Research·H Bartels
Jan 1, 1978·Human Heredity·S SarnaM Koskenvuo
Oct 1, 1992·Paediatric and Perinatal Epidemiology·E M Bryan
Mar 1, 1992·The Journal of Clinical Endocrinology and Metabolism·N R Farid
Nov 1, 1989·Endocrine Reviews·L J DeGroot, J Quintans
Oct 1, 1985·The Journal of Clinical Endocrinology and Metabolism·V StenszkyN R Farid
Mar 25, 1967·Lancet·A W EvansR W Evans
Apr 1, 1968·Acta geneticae medicae et gemellologiae·M HaugeT Videbech
Jan 1, 1994·Thyroid : Official Journal of the American Thyroid Association·J B Bertelsen, L Hegedüs
Feb 18, 1995·BMJ : British Medical Journal·K ChristensenA I Yashin
Sep 1, 1996·Pacing and Clinical Electrophysiology : PACE·M Møller, P Arnsbo
Jan 1, 1945·Acta Medica Scandinavica·E MEULENGRACHT

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Citations

Apr 2, 2009·Medizinische Klinik·Georg DultzGeorge J Kahaly
Nov 3, 2009·Clinical and Experimental Medicine·Omid KhalilzadehAliakbar Amirzargar
Jun 29, 2004·Human Immunology·Lara LevinYaron Tomer
Nov 26, 2008·Nature Clinical Practice. Endocrinology & Metabolism·Roberto VitaSalvatore Benvenga
Jun 26, 1998·Clinical Endocrinology·G Philippou, A M McGregor
May 14, 2004·The New England Journal of Medicine·George S Eisenbarth, Peter A Gottlieb
Jun 9, 2001·Thyroid : Official Journal of the American Thyroid Association·C Ruwhof, H A Drexhage
Feb 21, 2003·Thyroid : Official Journal of the American Thyroid Association·Yaron TomerDavid A Greenberg
Sep 13, 2002·Thyroid : Official Journal of the American Thyroid Association·Daniel A RingoldThomas Mack
Oct 16, 2003·Thyroid : Official Journal of the American Thyroid Association·R VillanuevaY Tomer
Aug 26, 1998·Thyroid : Official Journal of the American Thyroid Association·T H BrixL Hegedüs
Sep 16, 1998·Thyroid : Official Journal of the American Thyroid Association·T H BrixL Hegedüs
Oct 21, 2000·Thyroid : Official Journal of the American Thyroid Association·R VillanuevaT F Davies
Nov 18, 2000·Thyroid : Official Journal of the American Thyroid Association·T AkamizuD W Bowden
Mar 24, 2005·Thyroid : Official Journal of the American Thyroid Association·Antonio PetroneRaffaella Buzzetti
Jun 29, 2010·Thyroid : Official Journal of the American Thyroid Association·Terry F DaviesRauf Latif
Oct 28, 2011·Thyroid : Official Journal of the American Thyroid Association·Xin HouWeiping Teng
Nov 28, 2002·Journal of Pediatric Gastroenterology and Nutrition·Robert Pichler
May 28, 2013·BMC Endocrine Disorders·Christoph A RüstThomas Rosemann
Sep 30, 1999·Environmental Health Perspectives·G S CooperJ P Pandey
Sep 6, 2007·Endocrine Journal·Masami SasakiSan-E Ishikawa
Sep 13, 2012·European Journal of Endocrinology·Xander G VosWilmar M Wiersinga
Sep 17, 2013·Thyroid : Official Journal of the American Thyroid Association·Sara Salehi HammerstadKnut Dahl-Jørgensen
Oct 23, 2013·European Journal of Endocrinology·Bing-Li LiuHuai-Dong Song
Jan 28, 2014·Annual Review of Pathology·Yaron Tomer
Mar 27, 2001·Journal of Endocrinological Investigation·G PhilippouM Alevizaki
Mar 26, 2016·Frontiers in Endocrinology·Angela LombardiYaron Tomer
Aug 4, 2015·Journal of Autoimmunity·Hanna J LeeYaron Tomer
Aug 9, 2008·American Journal of Medical Genetics. Part a·Michael S HildebrandRichard J H Smith
Jan 3, 2013·Journal of Medical Virology·Sara Salehi HammerstadKnut Dahl-Jørgensen
Dec 16, 2011·Clinical Endocrinology·Thomas Heiberg Brix, Laszlo Hegedüs
May 26, 2004·Best Practice & Research. Clinical Endocrinology & Metabolism·Takao Ando, Terry F Davies
Jan 28, 2010·The American Journal of Medicine·Kristien BoelaertJayne A Franklyn
Apr 25, 2012·Journal of Thyroid Research·Terry F DaviesXiaoming Yin
Dec 30, 2011·Journal of Autoimmunity·Shashi AmurPadmaja Mummaneni
Dec 20, 2011·Journal of Autoimmunity·Dimitrios P BogdanosM Eric Gershwin
Jul 21, 2016·Immunologic Research·María-Teresa ArangoYehuda Shoenfeld
Jul 29, 2016·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Jing GongFu-Er Lu
Apr 27, 2012·Autoimmune Diseases·Paula Quintero-Ronderos, Gladis Montoya-Ortiz

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