A population-based study on the prevalence of NASH using scores validated against liver histology

Journal of Hepatology
Jenni HyysaloHannele Yki-Järvinen

Abstract

Non-alcoholic steatohepatitis (NASH) is a leading cause of chronic liver disease in Western countries. Diagnosis of NASH requires a liver biopsy. We estimated the prevalence of NASH non-invasively in a population-based study using scores validated against liver histology. Clinical characteristics, PNPLA3 genotype at rs738409, and serum cytokeratin 18 fragments were measured in 296 consecutive bariatric surgery patients who underwent a liver biopsy to discover and validate a NASH score ('NASH score'). We also defined the cut-off for NASH for a previously validated NAFLD liver fat score to diagnose NASH in the same cohort ('NASH liver fat score'). Both scores were validated in an Italian cohort comprising of 380, mainly non-bariatric surgery patients, who had undergone a liver biopsy for NASH. The cut-offs were utilized in the Finnish population-based D2D-study involving 2849 subjects (age 45-74 years) to estimate the population prevalence of NASH. The final 'NASH Score' model included PNPLA3 genotype, AST and fasting insulin. It predicted NASH with an AUROC 0.774 (0.709, 0.839) in Finns and 0.759 (0.711, 0.807) in Italians (NS). The AUROCs for 'NASH liver fat score' were 0.734 (0.664, 0.805) and 0.737 (0.687, 0.787), respectivel...Continue Reading

References

Nov 1, 1990·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·I R Wanless, J S Lentz
Mar 3, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·T M De FeoG Fiorelli
Jul 19, 2001·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·M CharltonK P Batts
Feb 6, 2003·Obesity Surgery·Antonio Del GaudioDaniela Munari
Sep 16, 2004·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Gary A AbramsRonald H Clements
May 26, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·David E KleinerUNKNOWN Nonalcoholic Steatohepatitis Clinical Research Network
Feb 2, 2006·Liver International : Official Journal of the International Association for the Study of the Liver·Nicole A PalekarStephen A Harrison
Aug 11, 2006·Journal of Hepatology·Mariana MachadoHelena Cortez-Pinto
Mar 30, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Paul AnguloChristopher P Day
May 23, 2007·International Journal of Circumpolar Health·Timo SaaristoUNKNOWN FIN-D2D Study Group
Apr 5, 2008·American Journal of Physiology. Gastrointestinal and Liver Physiology·Dario GrecoHannele Yki-Järvinen
May 27, 2008·Obesity Surgery·Zobair M YounossiAncha Baranova
Jun 16, 2009·Gastroenterology·Anna KotronenHannele Yki-Järvinen
Oct 13, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Giovanni MussoMaurizio Cassader
Sep 16, 2010·Journal of Gastroenterology·Yoshio SumidaUNKNOWN Japan Study Group of Nonalcoholic Fatty Liver Disease (JSG-NAFLD)
Dec 15, 2010·Journal of Hepatology·Tarek I Abu-Rajab TamimiAriel E Feldstein
Mar 8, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Silvia Sookoian, Carlos J Pirola
Apr 5, 2011·Liver International : Official Journal of the International Association for the Study of the Liver·Nathalie C LeiteGil F Salles
Aug 26, 2011·Surgery for Obesity and Related Diseases : Official Journal of the American Society for Bariatric Surgery·Jacob ChisholmLilian Kow
Dec 14, 2011·Alimentary Pharmacology & Therapeutics·N WlazloC D A Stehouwer
Feb 9, 2012·Journal of Hepatology·Jiayun ShenVincent Wai-Sun Wong
Aug 30, 2012·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Sudeep TanwarWilliam M Rosenberg
Nov 28, 2012·Journal of Hepatology·Mariana V Machado, Helena Cortez-Pinto
Dec 29, 2012·Emerging Themes in Epidemiology·Fraser I Lewis, Paul R Torgerson
Mar 1, 2013·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Marko SimonenJussi Pihlajamäki
Mar 20, 2013·Nature Reviews. Gastroenterology & Hepatology·Quentin M AnsteeChristopher P Day

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Citations

Mar 15, 2016·Metabolism: Clinical and Experimental·Naim Alkhouri, Ariel E Feldstein
Apr 18, 2016·Metabolism: Clinical and Experimental·Paula WalleJussi Pihlajamäki
Oct 3, 2015·Obesity Surgery·Kamal K MahawarPeter K Small
Jan 1, 2015·Nature Reviews. Disease Primers·Elizabeth M BruntMary E Rinella
Mar 30, 2016·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·L LiB Wang
May 16, 2014·Journal of Hepatology·Vincent Wai-Sun WongHenry Lik-Yuen Chan
Sep 28, 2015·Metabolism: Clinical and Experimental·Paola Dongiovanni, Luca Valenti
Jul 22, 2014·Journal of Gastroenterology and Hepatology·Munkhzul OtgonsurenZobair M Younossi
Apr 20, 2016·Diabetologia·Hannele Yki-Järvinen
Jun 18, 2016·International Journal of Molecular Sciences·Jonathan L TempleJude A Oben
Jan 28, 2016·Liver International : Official Journal of the International Association for the Study of the Liver·Zhenghui G JiangMichelle Lai
Jun 19, 2016·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·You ZhouHannele Yki-Järvinen
Dec 9, 2016·Thrombosis and Haemostasis·Susanna LallukkaHannele Yki-Järvinen
Mar 2, 2018·Liver International : Official Journal of the International Association for the Study of the Liver·Jane I GroveGuruprasad P Aithal
Oct 6, 2018·Alimentary Pharmacology & Therapeutics·Christian LabenzJörn M Schattenberg
Oct 25, 2016·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jari E KaikkonenOlli T Raitakari
Apr 14, 2015·World Journal of Hepatology·Marianthi PapagianniKonstantinos Tziomalos
Jul 20, 2019·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Fredrik ÅbergAntti Jula
Dec 24, 2014·Liver International : Official Journal of the International Association for the Study of the Liver·Ville T MännistöJussi Pihlajamäki
May 10, 2020·Liver International : Official Journal of the International Association for the Study of the Liver·Sami QadriHannele Yki-Järvinen
Jun 2, 2020·Scandinavian Journal of Gastroenterology·Florian GerhardtJohannes Wiegand
Sep 8, 2020·Expert Review of Gastroenterology & Hepatology·Letícia F RamosKaren C M Moraes
Mar 27, 2018·European Journal of Nutrition·I P KalafatiG V Dedoussis
Sep 7, 2018·The Journal of International Medical Research·Ajit Ramakant MahaleSonali Ullal
Apr 9, 2019·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Shih-Yi LinChia-Hung Kao
Nov 4, 2016·Nature Reviews. Gastroenterology & Hepatology·Herbert TilgMichael Roden
Mar 29, 2019·World Journal of Gastroenterology : WJG·Jiang-Hua ZhouHong-Liang Li
May 1, 2019·Journal of Nutritional Science·Paola VitaglioneFilomena Morisco
May 21, 2020·Diabetes & Metabolism Journal·Byung Wan LeeUNKNOWN Korean Diabetes Association (KDA) Fatty Liver Research Group
Nov 30, 2018·World Journal of Gastroenterology : WJG·Umberto Vespasiani-GentilucciAntonio Picardi
Oct 26, 2016·Liver International : Official Journal of the International Association for the Study of the Liver·Michael PavlidesEleanor Barnes

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