A Population-Based Study to Compare Treatment Outcomes Among Women With Urogenital Chlamydial Infection in Washington State, 1992 to 2015

Sexually Transmitted Diseases
Christine M KhosropourMatthew R Golden

Abstract

United States guidelines recommend azithromycin or doxycycline for chlamydia (Chlamydia trachomatis [CT]) treatment. These therapies are similarly efficacious for urogenital infections when outcomes are measured 7 to 42 days after treatment, although doxycycline may be superior for rectal infections. Some investigators have suggested that persistent rectal infections may lead to autoinfection of the urogenital tract, potentially resulting in higher rates of recurrent infection in azithromycin-treated women. We used Washington State surveillance data to identify women 14 years or older with urogenital CT (1992-2015) treated with azithromycin or doxycycline. We defined persistent/recurrent CT as a repeat positive CT test result 14 to 180 days after treatment of the initial infection. We used log binomial regression to estimate the adjusted relative risk (aRR) of persistent/recurrent infection associated with treatment with azithromycin versus doxycycline. From 1992 to 2015, there were 268,596 reported cases of urogenital CT, including 168,301 (63%) who received azithromycin and 66,432 (25%) who received doxycycline. The risk of persistent/recurrent urogenital CT was 6.7% and 4.7% in azithromycin- and doxycycline-treated cases, re...Continue Reading

References

Aug 1, 1992·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·J M OssewaardeA M van Loon
Jun 1, 1993·The Journal of Pediatrics·M R HammerschlagP M Roblin
Jan 1, 1997·American Journal of Obstetrics and Gynecology·S D HillisW R Mac Kenzie
Jun 28, 2000·The Australian & New Zealand Journal of Obstetrics & Gynaecology·F SendağM Güven
Jul 21, 2009·Sexually Transmitted Diseases·Christina B HosenfeldHeidi M Bauer
Mar 24, 2010·Obstetrics and Gynecology·Pennan M BarryJeffrey D Klausner
Apr 15, 2014·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·F Y S KongJ S Hocking
Oct 23, 2014·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Jennifer GratrixRon Read
Feb 1, 2015·The Journal of Antimicrobial Chemotherapy·Fabian Yuh Shiong KongJane S Hocking
May 10, 2015·International Journal of STD & AIDS·Kate MusilSarah Martin
Jul 30, 2015·BMC Infectious Diseases·Fabian Yuh Shiong Kong, Jane Simone Hocking
Dec 25, 2015·The New England Journal of Medicine·William M GeislerPeter R Kerndt
Jul 2, 2016·Infectious Diseases in Obstetrics and Gynecology·Philip A ChanErica J Hardy
Apr 4, 2017·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Geneviève A F S van LiereChristian J P A Hoebe

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Citations

Dec 22, 2020·American Journal of Obstetrics & Gynecology MFM·Jodie Dionne-OdomJeanne Marrazzo
Sep 4, 2021·Sexually Transmitted Diseases·Christine M KhosropourKevin Hybiske

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