Aug 8, 2014

A population genetic signal of polygenic adaptation

PLoS Genetics
Jeremy J Berg, Graham Coop

Abstract

Adaptation in response to selection on polygenic phenotypes may occur via subtle allele frequencies shifts at many loci. Current population genomic techniques are not well posed to identify such signals. In the past decade, detailed knowledge about the specific loci underlying polygenic traits has begun to emerge from genome-wide association studies (GWAS). Here we combine this knowledge from GWAS with robust population genetic modeling to identify traits that may have been influenced by local adaptation. We exploit the fact that GWAS provide an estimate of the additive effect size of many loci to estimate the mean additive genetic value for a given phenotype across many populations as simple weighted sums of allele frequencies. We use a general model of neutral genetic value drift for an arbitrary number of populations with an arbitrary relatedness structure. Based on this model, we develop methods for detecting unusually strong correlations between genetic values and specific environmental variables, as well as a generalization of [Q(ST)/F(ST)] comparisons to test for over-dispersion of genetic values among populations. Finally we lay out a framework to identify the individual populations or groups of populations that contrib...Continue Reading

Mentioned in this Paper

Genetic Drift
Genome-Wide Association Study
Diabetes Mellitus, Non-Insulin-Dependent
Meta-Analysis (Publications)
Genome
Polygenic Inheritance
Impacted Tooth
OCA2 gene
Dysequilibrium Syndrome
Recombination, Genetic

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