Nov 7, 2013

The Population Genetic Signature of Polygenic Local Adaptation

BioRxiv : the Preprint Server for Biology
Jeremy J. Berg, Graham Coop

Abstract

Adaptation in response to selection on polygenic phenotypes occurs via subtle allele frequencies shifts at many loci. Current population genomic techniques are not well posed to identify such signals. In the past decade, detailed knowledge about the specific loci underlying polygenic traits has begun to emerge from genome-wide association studies (GWAS). Here we combine this knowledge from GWAS with robust population genetic modeling to identify traits that have undergone local adaptation. Using GWAS data, we estimate the mean additive genetic value for a give phenotype across many populations as simple weighted sums of allele frequencies. We model the expected differentiation of GWAS loci among populations under neutrality to develop simple tests of selection across an arbitrary number of populations with arbitrary population structure. To find support for the role of specific environmental variables in local adaptation we test for correlations with the estimated genetic values. We also develop a general test of local adaptation to identify overdispersion of the estimated genetic values values among populations. This test is a natural generalization of QST /FST comparisons based on GWAS predictions. Finally we lay out a framew...Continue Reading

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Mentioned in this Paper

Genome-Wide Association Study
Genome
Polygenic Inheritance
Cell Differentiation Process
Quantitative Sensory Test
Genomics
Adaptation
Structure
Local
Analysis

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