A Population Pharmacokinetic Analysis of Dextroamphetamine in the Plasma and Hair of Healthy Adults

Clinical Drug Investigation
Jessica K RobertsCatherine M T Sherwin

Abstract

Hair is an attractive matrix for amphetamine drug testing; however, little is known about the rate at which amphetamines are deposited into hair. Therefore, the purpose of this study was to determine the pharmacokinetics of oral dextroamphetamine in plasma and quantify the rate of deposition into hair in healthy adults using a linked population pharmacokinetic model. Healthy adults >18 years of age received dextroamphetamine 10 mg orally for 7 days. Plasma samples were collected over 48 h following the final dose, and hair was collected 5 weeks following the first dose. NONMEM 7.2 was used to estimate dextroamphetamine oral absorption rate constant, apparent clearance and volume of distribution of the plasma compartment, the plasma to hair incorporation rate constant, and the apparent volume of distribution in the hair compartment. Dextroamphetamine pharmacokinetics were well-described by a one-compartment model with combined additive and proportional error for the plasma compartment, which was linked to a single compartment for the hair. Apparent clearance and volume of distribution in the plasma compartment were scaled by current body weight (centered on the mean). Melanin hair concentration was included as a significant cova...Continue Reading

References

Apr 1, 1979·Biochemical Pharmacology·B Larsson, H Tjälve
Nov 1, 1982·Biochemical Pharmacology·K B Stepień, T Wilczok
Apr 1, 1983·The Journal of Investigative Dermatology·S Ito, K Jimbow
Sep 1, 1995·The Journal of Investigative Dermatology·H OzekiT Hirobe
Dec 1, 1993·Analytical Biochemistry·S ItoH Ozeki
Oct 1, 1996·Journal of Analytical Toxicology·K M HöldR A Maes
Jan 1, 1996·Journal of Toxicology. Clinical Toxicology·R W ReidJ W Crayton
Aug 24, 1999·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·M V BachG B Baker
Nov 3, 2005·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Noriaki ShimaHitoshi Tsuchihashi
Mar 31, 2009·Brain Research Reviews·Irina N Krasnova, Jean Lud Cadet
Jul 10, 2013·CPT: Pharmacometrics & Systems Pharmacology·R J KeizerA Hooker

❮ Previous
Next ❯

Citations

May 5, 2016·Journal of the International AIDS Society·Randy M StalterUNKNOWN Consortium for Ring Adherence
Nov 24, 2020·Neurobiology of Learning and Memory·Lauren N Whitehurst, Sara C Mednick

❮ Previous
Next ❯

Related Concepts

Related Feeds

Addiction

This feed focuses mechanisms underlying addiction and addictive behaviour including heroin and opium dependence, alcohol intoxication, gambling, and tobacco addiction.