PMID: 11309548Apr 20, 2001Paper

A population pharmacokinetic screen to identify demographic-clinical covariates of basiliximab in liver transplantation

Clinical Pharmacology and Therapeutics
J M KovarikA Korn

Abstract

Basiliximab is a high-affinity interleukin-2 receptor (CD25) chimeric monoclonal antibody used for immunoprophylaxis in organ transplantation. It was assessed in a randomized, double-blind, placebo-controlled efficacy trial in de novo liver allograft recipients who received 40 mg of basiliximab (20 mg on days 0 and 4) in addition to baseline immunosuppression with cyclosporine (INN, ciclosporin) microemulsion and corticosteroids. Serial blood samples (8.3 +/- 1.4 per patient) were collected during 12 weeks after transplantation from 184 basiliximab-treated patients, and empirical Bayes estimates of each patient's disposition parameters were derived. Demographic-clinical covariates were explored with regression methods. Basiliximab clearance was 55 +/- 26 mL/h, the distribution volume was 9.7 +/- 4.2 L, and the half-life was 8.7 +/- 6.7 days. Patient weight, age, sex, ethnicity, history of alcoholism, hepatitis C seropositivity, and notable postoperative bleeding had no clinically relevant influences on basiliximab disposition; however, the cumulative volume of drained ascites fluid in the first week was positively correlated with clearance. Receptor-saturating basiliximab concentrations (> or =0.1 microg/mL) were maintained for...Continue Reading

Citations

Aug 2, 2005·Journal of Pediatric Gastroenterology and Nutrition·Abdulrahman Al-HussainiAnil Dhawan
Sep 8, 2010·Clinical Pharmacokinetics·Nathanael L Dirks, Bernd Meibohm
Jan 29, 2016·Clinical Pharmacokinetics·Katherine L GillManoranjenni Chetty
Jun 7, 2005·Expert Opinion on Drug Safety·Ugo BoggiFranco Mosca
Jul 9, 2002·Pediatric Transplantation·John M KovarikMichael Hall
Oct 12, 2010·Drug Metabolism and Pharmacokinetics·Akiko Ishii-WatabeYasuhiro Matsumura
Jan 20, 2012·Clinical Pharmacokinetics·Shuang BaiMark J Dresser
Jan 10, 2013·Clinical Pharmacokinetics·Miroslav DostalekManoranjenni Chetty
Feb 19, 2005·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·John FungBijan Eghtesad
Jul 19, 2002·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Gerit NiemeyerBjoern Nashan
Sep 29, 2005·Expert Opinion on Biological Therapy·David Ternant, Gilles Paintaud
Sep 2, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Juliette ThariatGerard Milano
Oct 22, 2003·Journal of Hepatology·Filomena ContiYvon Calmus
Sep 25, 2004·Journal of Pharmaceutical Sciences·Evelyn D LoboJoseph P Balthasar
Jul 26, 2005·Critical Reviews in Oncology/hematology·Anna L TaylorJ Andrew Bradley

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