Abstract
To study the relations between neuropeptide Y (NPY) and age, gender, blood pressure (BP) and risk factors for cardiovascular disease and the renin angiotensin system, we performed a population-based study through random selection of 220 subjects (49% men). Subjects on antihypertensive therapy were excluded and participation rate was 67%. Venous blood was drawn at 08.00 h in the fasting state and a Spacelab 90202/90207 ambulatory BP device was then fitted. Plasma NPY levels were normally distributed and the mean level was 144 +/- 17 pmol/L (mean +/- SD). There was a trend towards higher levels in women than in men (147 +/- 17 pmol/L and 142 +/- 17 pmol/L, respectively, p = 0.053). No correlations were found between NPY and ambulatory BP or clinic BP in either gender. Angiotensin II correlated positively with NPY in men but not in women (r = 0.27, p = 0.007). There were no correlations between NPY and body mass index, waist/hip ratio, BP or C-peptide in either gender. Total cholesterol (r = 0.39, p < 0.0001) and LDL-cholesterol (r = 0.35, p = 0.0001) were positively correlated with NPY in women only. The correlation remained in multiple regression analysis with plasma total or LDL- cholesterol as second independent variable to ag...Continue Reading
References
Mar 15, 1976·Clinica Chimica Acta; International Journal of Clinical Chemistry·A M KappelgaardJ Giese
Oct 1, 1992·Journal of Hypertension·D ErlingeL Edvinsson
Jun 1, 1992·Acta Endocrinologica·T LindströmH H von Schenck
Jan 1, 1992·Archives of Internal Medicine·P B BottiniL M Prisant
Feb 26, 1991·Regulatory Peptides·L EdvinssonT Thulin
Jan 1, 1990·The Journal of Clinical Investigation·P ValetM Lafontan
Nov 1, 1990·American Journal of Hypertension·V B SoltM G Ziegler
Apr 1, 1989·Hypertension·B C BerkT Tsuda
Dec 1, 1988·Diabetes·G M Reaven
Dec 1, 1987·Journal of Hypertension·K TakahashiK Yoshinaga
May 1, 1968·Acta Medica Scandinavica·L A CarlsonJ Ostman
Sep 1, 1983·Circulation·R B DevereuxJ H Laragh
Jan 1, 1994·Neuroscience and Biobehavioral Reviews·M C LeeT N Pappas
Apr 1, 1995·Journal of Hypertension·M C Michel, W Rascher
Apr 1, 1995·Neurochemistry International·M Heilig, R Ekman
May 1, 1995·Blood Pressure·B WocialZ Zukowska-Grojec
Mar 17, 1994·Regulatory Peptides·D ErlingeL Edvinsson
Feb 1, 1994·Hypertension·P PalatiniA C Pessina
Citations
Jul 20, 2002·Peptides·Philippe NaveilhanPatrik Ernfors
Feb 19, 2008·Public Health Nutrition·Marika SalminenSirkka-Liisa Kivelä
Jan 27, 1999·Annals of Medicine·M I UusitupaM Koulu
Nov 24, 2011·Evidence-based Complementary and Alternative Medicine : ECAM·Mi Mi KoMin Ho Cha
Nov 13, 2016·European Psychiatry : the Journal of the Association of European Psychiatrists·J-P KlemettiläE Leinonen
Dec 10, 1998·Nature Medicine·M K KarvonenM I Uusitupa
Aug 25, 2020·Mediators of Inflammation·Hao-Neng TangHou-De Zhou
Aug 16, 2001·Cancer·A JatoiH E Windschitl
Sep 26, 2020·Life Sciences·Fu ChenYong Wang