A population study of plasma neuropeptide Y: correlations with components of the metabolic syndrome

Blood Pressure
F NyströmK P Ohman

Abstract

To study the relations between neuropeptide Y (NPY) and age, gender, blood pressure (BP) and risk factors for cardiovascular disease and the renin angiotensin system, we performed a population-based study through random selection of 220 subjects (49% men). Subjects on antihypertensive therapy were excluded and participation rate was 67%. Venous blood was drawn at 08.00 h in the fasting state and a Spacelab 90202/90207 ambulatory BP device was then fitted. Plasma NPY levels were normally distributed and the mean level was 144 +/- 17 pmol/L (mean +/- SD). There was a trend towards higher levels in women than in men (147 +/- 17 pmol/L and 142 +/- 17 pmol/L, respectively, p = 0.053). No correlations were found between NPY and ambulatory BP or clinic BP in either gender. Angiotensin II correlated positively with NPY in men but not in women (r = 0.27, p = 0.007). There were no correlations between NPY and body mass index, waist/hip ratio, BP or C-peptide in either gender. Total cholesterol (r = 0.39, p < 0.0001) and LDL-cholesterol (r = 0.35, p = 0.0001) were positively correlated with NPY in women only. The correlation remained in multiple regression analysis with plasma total or LDL- cholesterol as second independent variable to ag...Continue Reading

References

Mar 15, 1976·Clinica Chimica Acta; International Journal of Clinical Chemistry·A M KappelgaardJ Giese
Oct 1, 1992·Journal of Hypertension·D ErlingeL Edvinsson
Nov 1, 1990·American Journal of Hypertension·V B SoltM G Ziegler
Apr 1, 1995·Journal of Hypertension·M C Michel, W Rascher

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Citations

Nov 24, 2011·Evidence-based Complementary and Alternative Medicine : ECAM·Mi Mi KoMin Ho Cha
Nov 13, 2016·European Psychiatry : the Journal of the Association of European Psychiatrists·J-P KlemettiläE Leinonen

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