A porcine model for pathomorphological age assessment of surgically excised skin wounds

Acta Veterinaria Scandinavica
Kristiane BaringtonHenrik Elvang Jensen

Abstract

A porcine model of second intention wound healing was established and gross and histological changes needed for accurate assessing the age of wounds were determined. Twenty-five pigs were anesthetized before incision of four wounds on each. The wounds were left to heal from 1 h to 35 days when the pigs were euthanized. In 14 pigs, biopsies were sampled from two wounds between days 2 and 18. By histological evaluation the following characteristics were found useful for determining the age of wounds: neutrophil:macrophage ratio, angiogenesis, hyperplasia of fibroblasts, presence of hemosiderophages and granulation tissue. The latter was present from day 4 (n = 8 wounds, 100%), but by gross evaluation it was not recognized until day 5 (n = 4 wounds, 100%). From day 4 to 10, the thickness of granulation tissue increased by 1.2 ± 2.4 mm/day. The thickness of collagen fibers within granulation tissue increased throughout the study period, and complete epithelization was reached from day 18.

References

Jan 1, 1991·Memórias do Instituto Oswaldo Cruz·G S Montes, L C Junqueira
Oct 1, 1988·International Journal of Dermatology·H BouissouJ Kokolo
Mar 27, 2001·Connective Tissue Research·J F WangD A Hart
Feb 15, 2007·The Journal of Investigative Dermatology·Sabine A EmingJeffrey M Davidson
Apr 24, 2013·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Haytham ElgharablyChandan K Sen
Dec 30, 2015·Veterinary Pathology·D J MeutenJ W George
Jul 7, 2016·Veterinary Pathology·L ResselE Ricci
Jul 16, 2016·Veterinary Pathology·A de SiqueiraP C Maiorka
Jul 17, 2016·Acta Veterinaria Scandinavica·Kristiane BaringtonHenrik Elvang Jensen
Jan 26, 2017·Research in Veterinary Science·Kristiane Barington, Henrik Elvang Jensen

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