A porcine polytrauma model with two different degrees of hemorrhagic shock: outcome related to trauma within the first 48 h

European Journal of Medical Research
D EschbachK Horst

Abstract

An animal polytrauma model was developed, including trunk and extremity injuries combined with hemorrhagic shock and a prolonged post-traumatic phase. This could be useful for the assessment of different therapeutic approaches during intensive care therapy. A standardized polytrauma including lung contusion, liver laceration and lower leg fracture was applied in 25 pigs. They underwent controlled haemorrhage either with a blood volume loss of 45 % and a median arterial pressure (MAP) <30 mmHg/90 min (group L, n = 15) or a 50 % blood loss of and an MAP <25 mmHg/120 min (group H, n = 10). Five non-traumatized pigs served as a control (group C). Subsequently, intensive care treatment was given for an observational period of 48 h. Both trauma groups showed signs of shock and organ injury (heart rate, MAP and lactate). The frequency of cardiopulmonary resuscitation (CPR) and lung injury was directly related to the severity of the haemorrhagic shock (CPR-group L: 4 of 15 pigs, group H: 4 of 10 pigs; Respiratory failure-group L: 3 of 13, group H: 3 of 9. There was no difference in mortality between trauma groups. The present data suggest that our model reflects the mortality and organ failure of polytrauma in humans during shock and t...Continue Reading

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Citations

Oct 3, 2017·Technology and Health Care : Official Journal of the European Society for Engineering and Medicine·D EschbachM Frink
Aug 31, 2020·European Journal of Trauma and Emergency Surgery : Official Publication of the European Trauma Society·Albin DahlquistMattias Günther
Dec 14, 2018·Wiener medizinische Wochenschrift·Tim KornfeldChristine Radtke
Jan 1, 2020·World Journal of Emergency Surgery : WJES·Juan José Segura-SampedroFrancesc Xavier González-Argente
Jan 12, 2021·Computational and Mathematical Methods in Medicine·Luciano CurcioAndrea De Gaetano
Oct 7, 2020·European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes·Weijun GuoKlemens Horst

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