PMID: 1380785Jan 1, 1992Paper

A pore transport model for pulmonary alveolar epithelium

Annals of Biomedical Engineering
T ChandraD B Yeates


Hydrodynamic heteropore flow models for transport of solutes across alveolar epithelial tissue have been developed. A two-size cylindrical pore model and a similar parallel-plate model were formulated, tested and used to predict effective pore sizes from literature data on transport in bullfrog, canine and rat lungs. The best fit equivalent pore-size estimates were obtained using a modified, nonlinear least squares procedure, with alveolar surface area to volume ratio (S/V) and small-pore area fraction of total pore area as parameters. Small-pore and large-pore width estimates of 4 nm (84% of total flow area) and 10 nm, respectively, with an average deviation of 20% from experimentally derived permeabilities were obtained from the bullfrog alveolar epithelium parallel-plate pore model (13 solutes, diameters 0.3 to 2.8 nm). The equivalent cylindrical pore model diameter estimates were 5 nm and 10 nm, with small-pore area fraction and percentage deviations similar to the parallel-plate model estimates. Eighty-eight percent of the bulk water driven by a sucrose osmotic gradient was predicted to be transported through the small pores. The rat alveolus parallel-plate pore model (6 solutes) yielded small-pore and large-pore widths of...Continue Reading


Sep 1, 1975·Proceedings of the Society for Experimental Biology and Medicine·T H Gardiner, L S Schanker
Oct 1, 1975·The American Journal of Physiology·J TheodoreJ Acevedo
Dec 1, 1987·The American Journal of Physiology·B Gumbiner
Nov 1, 1986·The American Review of Respiratory Disease·G OberdörsterD A Weber
Dec 1, 1971·The Journal of Physiology·I C NormandL B Strang
Apr 11, 1970·The American Journal of Physiology·A E Taylor, K A Gaar
Jun 1, 1966·The Journal of Physiology·M Altamirano, C Martinoya
Nov 1, 1984·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·S F ManJ C Hogg
Jan 1, 1983·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·K J Kim, E D Crandall
Jun 1, 1981·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·E D Crandall, K J Kim
May 1, 1982·Experimental Lung Research·J T Gatzy
Nov 1, 1980·British Journal of Industrial Medicine·M LippmannR E Albert
Mar 20, 1956·The Journal of General Physiology·R P DURBINA K SOLOMON
Sep 1, 1959·Journal of Clinical Pathology·B E TOMLINSON

Related Concepts

Vascular Permeability
Canis familiaris
Endothelium, Vascular
Particle Size
Pulmonary Alveolar Structure
Rats, Laboratory

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