A portrait of germline mutation in Brazilian at-risk for hereditary breast cancer

Breast Cancer Research and Treatment
Ana Rafaela de Souza TimoteoTirzah Braz Petta Lajus

Abstract

Knowledge about the germline mutational spectrum among Brazilian with hereditary breast and ovarian cancer (HBOC) is limited. Only five studies have performed comprehensive BRCA sequencing, corresponding to 1041 individuals among a Brazilian population of over 207 million people. Herein we aimed to determine the clinical and molecular characteristics of Brazilian patients who underwent oncogenetic counseling and genetic testing of a panel of high-risk and moderate-risk genes from 2009 to 2017. Massively parallel sequencing was applied in 157 individuals (132 breast cancer-affected and 25 breast cancer-unaffected individuals) selected according NCCN criteria for hereditary breast cancer. Analysis of mutation segregation in family members was performed by capillary bidirectional sequencing, clinical response after treament and survival analysis was estimated by Kaplan-Meier. Nineteen germline variants were identified,15 pathogenic and 4 VUS (Variants of Uncertain Significance) in 27 individuals (27/157; 17% P < 0.0001) distributed among 7 genes. Sixty-eight percent of patients (13/19) harbor mutation in BRCA genes and 32% (6/19) in moderate risk genes. This is the first study reporting ATR deleterious germline mutation in associa...Continue Reading

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Citations

Mar 11, 2020·JCO Global Oncology·Maria Isabel AchatzPatricia Ashton-Prolla
Sep 29, 2020·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Gabriel BandeiraOswaldo Keith Okamoto
Jun 6, 2021·Molecular and Cellular Biochemistry·Fernanda Valente GhelerFernanda Bueno Morrone

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