PMID: 7540183Mar 1, 1995Paper

A positive correlation between expression of beta 1-integrin cell adhesion molecules and fertilizing ability of human spermatozoa in vitro

Human Reproduction
L D KlentzerisS Green

Abstract

The purpose of this study was to investigate firstly whether beta 1-integrin cell adhesion molecules are expressed by human spermatozoa, and secondly whether there is any relationship between the expression of beta 1-integrin cell adhesion molecules and the fertilizing ability of human spermatozoa in vitro. A total of 50 semen samples were examined. The samples were obtained from the male partners of couples undergoing in-vitro fertilization (IVF) for either unexplained, tubal or male factor infertility. A panel of six monoclonal antibodies against beta 1-integrin cell adhesion molecules and immunohistochemical techniques were used to identify the presence of these molecules on the spermatozoa. The percentage of spermatozoa showing strong immunolabelling with each monoclonal antibody was assessed in each sample. The relationship between these results and the aetiology of infertility and incidence of fertilization was examined. beta 1-Integrins, and primarily the ones with alpha 4-, alpha 5- and alpha 6-chains, were expressed by human spermatozoa. Compared with semen samples from unexplained or male factor infertility patients, samples from tubal infertility patients had a significantly higher (P < 0.05) percentage of spermatozo...Continue Reading

Citations

Apr 1, 1997·British Journal of Obstetrics and Gynaecology·L D Klentzeris
Mar 30, 2001·Human Reproduction·C de Vantéry ArrighiD Chardonnens
Mar 1, 2019·International Journal of Molecular Sciences·Michaela FrolikovaKaterina Dvorakova-Hortova
Nov 5, 1997·Annals of the New York Academy of Sciences·B A Lessey
Nov 8, 2014·Reproductive Sciences·Gayatri MohantyLuna Samanta
Mar 18, 2000·Proceedings of the Society for Experimental Biology and Medicine·J A Bowen, J S Hunt
Nov 15, 2020·International Journal of Molecular Sciences·Virginie Barraud-LangeAhmed Ziyyat
Sep 14, 2007·BMC Developmental Biology·Virginie Barraud-LangeAhmed Ziyyat

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