A Positive Feedback Loop Comprising LHW-TMO5 and Local Auxin Biosynthesis Regulates Initial Vascular Development in Arabidopsis Roots

Plant & Cell Physiology
Kyoko Ohashi-ItoHiroo Fukuda

Abstract

The phytohormone auxin governs various developmental processes in plants including vascular formation. Auxin transport and biosynthesis are important factors in determining auxin distribution in tissues. Although the role of auxin transport in vein pattern formation is widely recognized, that of auxin biosynthesis in vascular development is poorly understood. Heterodimer complexes comprising two basic helix-loop-helix protein families, LONESOME HIGHWAY (LHW) and TARGET OF MONOPTEROS5 (TMO5)/TMO5-LIKE1 (T5L1), are master transcriptional regulators of the initial process of vascular development. The LHW-TMO5/T5L1 dimers regulate vascular initial cell production, vascular cell proliferation and xylem fate determination in the embryo and root apical meristem (RAM). In this study, we investigated the function of local auxin biosynthesis in initial vascular development in RAM. Results showed that LHW-T5L1 upregulated the expression of YUCCA4 (YUC4), a key auxin biosynthesis gene. The expression of YUC4 was essential for promoting xylem differentiation and vascular cell proliferation in RAM. Conversely, auxin biosynthesis was required for maintaining the expression levels of LHW, TMO5/T5L1 and their targets. Our results suggest that l...Continue Reading

References

Aug 17, 2005·Genes & Development·Minoru KuboTaku Demura
Jul 13, 2007·Development·Kyoko Ohashi-Ito, Dominique C Bergmann
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Jul 24, 2012·The Plant Cell·Kengo MorohashiErich Grotewold
Jan 30, 2013·Plant & Cell Physiology·Kyoko Ohashi-ItoHiroo Fukuda
Jan 31, 2013·Development·Kyoko Ohashi-ItoHiroo Fukuda
Dec 3, 2013·Current Biology : CB·Hélène S RobertJiří Friml
Apr 30, 2014·Molecular Plant·Simona BaimaGiorgio Morelli
Aug 19, 2014·Current Biology : CB·Kyoko Ohashi-ItoHiroo Fukuda
Nov 27, 2015·Developmental Cell·Francisco Vera-SireraMiguel A Blázquez
Mar 24, 2016·Proceedings of the National Academy of Sciences of the United States of America·Hidefumi ShinoharaYoshikatsu Matsubayashi
Dec 27, 2017·Current Opinion in Plant Biology·Nguyen Manh LinhEnrico Scarpella
Nov 13, 2018·Developmental Cell·Javier BrumosAnna N Stepanova

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Citations

Oct 19, 2020·The New Phytologist·Tomás M TessiMarcelo Desimone
May 19, 2021·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·Xiaohui ZhangDengfeng Hong

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