Abstract
Teucrium stocksianum (T. stocksianum) is one of the important members of the genus Teucrium which contains numerous biologically active compounds. Traditionally, it is used for the treatment of fever, pain, as expectorant and blood purifier. Researchers are trying to discover plants origin, novel and safe remedies for the management of various ailments. The present study was aimed to determine the possible anti-inflammatory mechanism of ethyl acetate extract of T. stocksianum. Preliminary, the ethanolic extract and sub-fractions were screened for anti-inflammatory potential at doses of 100, 200 and 300 mg/kg (i.p) body weight, using carrageenan induced paw edema test in mice. In-order to determine the possible mechanism of anti-inflammatory effect, the ethyl acetate fraction was ascertained with different phlogistic agents like histamine, bradykinin, prostaglandins E2 and arachedonic acid via paw edema test in mice. The ethanolic extract and sub-fractions of T. stocksianum displayed marked to moderate anti-inflammatory activity in a carrageenan induced paw edema test in mice. Among the sub-fractions, ethyl acetate fraction (EAF) demonstrated excellent (66%) anti-inflammatory action at the highest tested dose (300 mg/kg) that re...Continue Reading
References
Aug 1, 1987·Agents and Actions·M J DiMartinoN Hanna
Sep 1, 1974·The Journal of Pharmacy and Pharmacology·M J SmithJ P Bolam
Apr 9, 1998·Pharmacology·S SánchezM E Planas
Mar 27, 2001·Phytotherapy Research : PTR·P SurD K Ganguly
Jul 14, 2001·Journal of Pharmaceutical and Biomedical Analysis·G Zgórka, K Głowniak
Nov 13, 2004·Journal of Pharmacological Sciences·Hyun Pyo KimSam Sik Kang
Dec 14, 2005·Journal of Ethnopharmacology·Shabana Channa Atta-Ur-Rahman
Jun 3, 2008·Cellular and Molecular Life Sciences : CMLS·A SalminenJ Huuskonen
Sep 23, 2008·Basic & Clinical Pharmacology & Toxicology·Adeolu A AdedapoAnthony J Afolayan
Nov 5, 2011·BMC Complementary and Alternative Medicine·Niaz AliImran Khan
May 4, 2012·BMC Complementary and Alternative Medicine·Naveed MuhammadHaroon Khan
Dec 12, 2012·BMC Complementary and Alternative Medicine·Syed Muhammad Mukarram ShahAbdul Sadiq
Jun 5, 2014·BMC Complementary and Alternative Medicine·Syed Muhammad Mukarram ShahFarhat Ullah
Mar 3, 2015·Biological Research·Syed Muhammad ShahShahzeb Khan
Jan 27, 2016·BMC Complementary and Alternative Medicine·Sajjad AhmadMuhammad Raza Shah
Citations
Oct 26, 2011·BMC Complementary and Alternative Medicine·Niaz AliImran Khan
Aug 22, 2016·Journal of Ethnopharmacology·Mohammed Junaid KhanShailendra Saraf
Oct 9, 2015·BMC Complementary and Alternative Medicine·Syed Muhammad Mukarram Shah, Syed Muhammad Hassan Shah
Apr 24, 2020·Journal of Basic and Clinical Physiology and Pharmacology·Aristide Laurel Mokale KognouRosalie Annie Ngono Ngane
Jul 22, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Nadia HisamuddinMadihah Talib
Nov 5, 2020·Respiratory Physiology & Neurobiology·Basma IjazNawazish-I-Husain Syed