A possible anti-inflammatory mechanism of ethyl acetate extracts of Teucrium stocksianum Bioss

BMC Complementary and Alternative Medicine
Syed Muhammad Mukarram Shah

Abstract

Teucrium stocksianum (T. stocksianum) is one of the important members of the genus Teucrium which contains numerous biologically active compounds. Traditionally, it is used for the treatment of fever, pain, as expectorant and blood purifier. Researchers are trying to discover plants origin, novel and safe remedies for the management of various ailments. The present study was aimed to determine the possible anti-inflammatory mechanism of ethyl acetate extract of T. stocksianum. Preliminary, the ethanolic extract and sub-fractions were screened for anti-inflammatory potential at doses of 100, 200 and 300 mg/kg (i.p) body weight, using carrageenan induced paw edema test in mice. In-order to determine the possible mechanism of anti-inflammatory effect, the ethyl acetate fraction was ascertained with different phlogistic agents like histamine, bradykinin, prostaglandins E2 and arachedonic acid via paw edema test in mice. The ethanolic extract and sub-fractions of T. stocksianum displayed marked to moderate anti-inflammatory activity in a carrageenan induced paw edema test in mice. Among the sub-fractions, ethyl acetate fraction (EAF) demonstrated excellent (66%) anti-inflammatory action at the highest tested dose (300 mg/kg) that re...Continue Reading

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Citations

Oct 26, 2011·BMC Complementary and Alternative Medicine·Niaz AliImran Khan
Oct 9, 2015·BMC Complementary and Alternative Medicine·Syed Muhammad Mukarram Shah, Syed Muhammad Hassan Shah
Apr 24, 2020·Journal of Basic and Clinical Physiology and Pharmacology·Aristide Laurel Mokale KognouRosalie Annie Ngono Ngane

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