A possible approach to improving the reproducibility of urinary concentrations of phthalate metabolites and phenols during pregnancy

Journal of Exposure Science & Environmental Epidemiology
Mahsa M YazdySusan A Korrick

Abstract

In epidemiologic studies, classifying episodic exposures to chemicals with short half-lives, such as phthalates and phenols, is challenging. We assessed whether accounting for sources of variability unrelated to exposure pathways would improve the reproducibility of urine concentrations of select phthalate metabolites and phenols. In 2011, a subset of pregnant women (n = 19) enrolled in a prospective study provided first morning urine samples every 3-4 weeks between 16 and 36 weeks gestation. At the time of collection, we identified potential contributors to variations in urinary concentrations: weight gain, gestational age, time slept, time since awoke, time since last food/drink, and time since last void. We estimated intraclass correlation coefficients (ICCs) among repeat urine concentrations with and without adjustment for sources of variability using a random intercept linear mixed model. Concentrations of monoethyl phthalate, butyl, and propyl parabens were the most reproducible (ICCs: 0.68, 0.56, and 0.56, respectively). However, adjustment for potential sources of variability unrelated to exposure pathways did not materially improve reproducibility nor the ability of a single sample to predict exposure based on average ...Continue Reading

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Citations

Feb 16, 2019·Toxicological Sciences : an Official Journal of the Society of Toxicology·Genoa R WarnerJodi A Flaws
May 12, 2019·Biology of Reproduction·Saniya Rattan, Jodi A Flaws
May 21, 2021·Reproductive Toxicology·Genoa R WarnerJones B Graceli

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Methods Mentioned

BETA
urine collection
urine collections

Software Mentioned

Statistical Analysis
SAS

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