A possible association between elevated serum levels of brain-specific auto-antibodies and reduced plasma levels of docosahexaenoic acid in autistic children

Journal of Neuroimmunology
Gehan Ahmed MostafaLaila Yousef Al-Ayadhi

Abstract

Polyunsaturated fatty acids (PUFAs) are not only essential for energy production, but they also exhibit a range of immunomodulatory properties that progress through T cell mediated events. Autoimmunity may have a pathogenic role in a subgroup of autistic children. This study is the first to investigate the relationship between serum levels of anti-myelin basic protein (anti-MBP) brain-specific auto-antibodies and reduced plasma levels of PUFAs in autistic children. Plasma levels of PUFAs (including linoleic, alphalinolenic, arachidonic "AA" and docosahexaenoic "DHA" acids) and serum anti-MBP were measured in 80 autistic children, aged between 4 and 12 years, and 80 healthy-matched children. Autistic patients had significantly lower plasma levels of PUFAs than healthy children. On the other hand, ω6/ω3 ratio (AA/DHA) was significantly higher in autistic patients than healthy children. Low plasma DHA, AA, linolenic and linoleic acids were found in 67.5%, 50%, 40% and 35%, respectively of autistic children. On the other hand, 70% of autistic patients had elevated ω6/ω3 ratio. Autistic patients with increased serum levels of anti-MBP auto-antibodies (75%) had significantly lower plasma DHA (P<0.5) and significantly higher ω6/ω3 rat...Continue Reading

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Citations

Mar 5, 2016·Neurochemistry International·Enie LeiWah Chin Boon
Apr 29, 2015·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Gang ZhaoLijie Wu
Apr 1, 2016·Pediatric Annals·Annio Posar, Paola Visconti
Jul 1, 2017·Critical Reviews in Food Science and Nutrition·Carlos CardosoNarcisa M Bandarra
Mar 19, 2019·Critical Reviews in Food Science and Nutrition·Bárbara P MartinsMargarida Figueiredo-Braga

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