A possible contribution of lipocalin-2 to the development of dermal fibrosis, pulmonary vascular involvement and renal dysfunction in systemic sclerosis

The British Journal of Dermatology
Takehiro TakahashiShinichi Sato

Abstract

Lipocalin-2 is an adipocytokine implicated in apoptosis, innate immunity, angiogenesis, and the development of chronic kidney disease. To investigate the role of lipocalin-2 in systemic sclerosis (SSc). Serum lipocalin-2 levels were determined by enzyme-linked immunosorbent assay in 50 patients with SSc and 19 healthy subjects. Lipocalin-2 expression was evaluated in the skin of patients with SSc and bleomycin (BLM)-treated mice and in Fli1-deficient endothelial cells by reverse transcriptase-real time polymerase chain reaction, immunoblotting and/or immunohistochemistry. Although serum lipocalin-2 levels were comparable between patients with SSc and healthy controls, the prevalence of scleroderma renal crisis was significantly higher in patients with SSc with elevated serum lipocalin-2 levels than in those with normal levels. Furthermore, serum lipocalin-2 levels inversely correlated with estimated glomerular filtration rate in patients with SSc with renal dysfunction. Among patients with SSc with normal renal function, serum lipocalin-2 levels positively correlated with skin score in patients with diffuse cutaneous SSc with disease duration of < 3 years and inversely correlated with estimated right ventricular systolic pressu...Continue Reading

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Citations

Jan 20, 2016·The Journal of Dermatology·Yoshihide Asano
Jul 15, 2015·Seminars in Immunopathology·Yoshihide Asano, Shinichi Sato
Feb 19, 2017·Autoimmunity Reviews·Sabrina HoaUNKNOWN Scleroderma Clinical Trials Consortium Scleroderma Renal Crisis Working Group Investigators of the Scleroderma Clinical Tria
Apr 4, 2017·Experimental Dermatology·Tetsuo ToyamaShinichi Sato
May 23, 2017·The Journal of Investigative Dermatology·Ryosuke SaigusaShinichi Sato
Feb 25, 2017·The Journal of Experimental Medicine·Takehiro TakahashiShinichi Sato
Dec 12, 2017·The Journal of Dermatology·Yoshihide Asano
Dec 7, 2018·The Journal of Investigative Dermatology·Takashi YamashitaShinichi Sato

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