A possible explanation for the low incidence of gonosomal aneuploidy among the offspring of triplo-X individuals

American Journal of Medical Genetics
G Neri

Abstract

A review of the reproductive performance of 47,XXX individuals showed that the incidence of gonosomal aneuploidy among the offspring is low. To explain this unexpected phenomenon it is hypothesized that fertile triplo-X individuals have chromosomally normal oogonia due to mitotic nondisjunction in a cell from which the primordial germ line took origin. Mosaic 46,XX/47,XXX individuals have a somewhat higher risk of bearing aneuploid offspring, possibly due to a constitutional tendency toward gonosomal nondisjunction.

References

Apr 1, 1978·Journal of Medical Genetics·J Dewhurst
Aug 1, 1976·Journal of Medical Genetics·I HayataA A Sandberg
Dec 1, 1976·Journal of Medical Genetics·R Guzmán-ToledanoM Jimenez
Mar 1, 1975·Journal of Medical Genetics·M T TsuangL E De Bault
Oct 20, 1975·Humangenetik·J Nielsen, I Sillesen
Apr 29, 1972·Lancet·M GeislerK H Degenhardt
Mar 25, 1972·Lancet·A G BaikieJ N Lickiss
Jun 1, 1972·Journal of Medical Genetics·J SingerD Y Hsia
May 1, 1974·Annals of Human Genetics·P A JacobsJ Syme
Jan 1, 1969·British Medical Bulletin·R R Race, R Sanger
Jul 1, 1967·Fertility and Sterility·W Futterweit
May 1, 1983·Clinical Genetics·J P FrynsH van den Berghe
Oct 1, 1980·Annals of Human Genetics·T HassoldP A Jacobs
Jul 2, 1960·Lancet·J S STEWART, A R SANDERSON
Dec 28, 1963·Lancet·H G CLOSE
May 1, 1964·Fertility and Sterility·J RABOCH
May 1, 1965·Lancet·W ROSENKRANZ
Jan 1, 1976·Cytogenetics and Cell Genetics·A GroppK Fredga

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Citations

May 13, 2010·Orphanet Journal of Rare Diseases·Nicole R TartagliaLennie Wilson
Jan 27, 2004·Wiener klinische Wochenschrift·Christian J GruberJohannes C Huber
Feb 14, 2012·Current Problems in Pediatric and Adolescent Health Care·Patricia L Crotwell, H Eugene Hoyme
Oct 1, 1985·American Journal of Medical Genetics·J T Bensen, M W Steele

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