PMID: 11914114Mar 27, 2002Paper

A possible extratubular origin of epididymal basal cells in mice

Reproduction : the Official Journal of the Society for the Study of Fertility
C Holschbach, T G Cooper

Abstract

The origin of basal cells in mouse epididymis was examined by counting the numbers of basal cells, intratubular mitotic figures and peritubular cells during development of the epididymis. Putative precursors of basal cells were labelled with bromodeoxyuridine and the nuclei of daughter cells were examined. Histochemical localization of cytokines was performed to gauge their involvement in migration of basal cell precursors from extratubular sources. The results indicate that basal cells may arise from extratubular sources as: (i) there was a decrease in the number of mitotic figures as the number of basal cells increased; (ii) no mitotic figures were observed in the base of the epithelium; (iii) the increase in the number of peritubular cells did not parallel the number of basal cells in all epididymal regions; (iv) division of epithelial cells into daughter cells was circumferential and not radial; (v) bromodeoxyuridine-labelled basal cell nuclei were mostly not found in the vicinity of labelled principal cell nuclei and vice versa; and (vi) the percentage of labelled basal cell nuclei was higher than that of the other cells, which is indicative of their arrival from a more highly labelled pool. In addition, no age-dependent c...Continue Reading

Citations

Jul 28, 2007·International Urology and Nephrology·Hayrettin OzturkAli Ihsan Dokucu
Oct 22, 2013·Reproduction, Fertility, and Development·S Arrighi
Jul 14, 2007·Fertility and Sterility·Ji-Geng YanHani S Matloub
Feb 27, 2007·Tissue & Cell·Raquel Fantin DomeniconiSérgio Luis Felisbino
Jun 10, 2008·Anatomia, histologia, embryologia·T A AireM-C Madekurozwa
Jan 15, 2014·Theriogenology·C M Bernal-MañasL M Pastor
Mar 22, 2014·Biology of Reproduction·Winnie W ShumNicolas Da Silva
Jul 3, 2004·Reproduction : the Official Journal of the Society for the Study of Fertility·M Michael AruldhasM A Akbarsha
Aug 21, 2013·Reproduction : the Official Journal of the Society for the Study of Fertility·Winnie W C ShumSylvie Breton
Feb 27, 2008·Reproduction : the Official Journal of the Society for the Study of Fertility·K FaisalM A Akbarsha

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